Glucose-Dependent Insulinotropic Polypeptide—A Postprandial Hormone with Unharnessed Metabolic Potential

Autor:	Nunzio, Guccio, Fiona M, Gribble, Frank, Reimann
Rok vydání:	2022
Předmět:	Glucose Nutrition and Dietetics Diabetes Mellitus Type 2 Humans Medicine (miscellaneous) Gastric Inhibitory Polypeptide Obesity Postprandial Period
Zdroj:	Annual Review of Nutrition. 42:21-44
ISSN:	1545-4312 0199-9885
DOI:	10.1146/annurev-nutr-062320-113625
Popis:	Glucose-dependent insulinotropic polypeptide (GIP) is released from the upper small intestine in response to food intake and contributes to the postprandial control of nutrient disposition, including of sugars and fats. Long neglected as a potential therapeutic target, the GIPR axis has received increasing interest recently, with the emerging data demonstrating the metabolically favorable outcomes of adding GIPR agonism to GLP-1 receptor agonists in people with type 2 diabetes and obesity. This review examines the physiology of the GIP axis, from the mechanisms underlying GIP secretion from the intestine to its action on target tissues and therapeutic development.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa75023b8c80460ed3ef82ee00f6e978 https://doi.org/10.1146/annurev-nutr-062320-113625 Zobrazit plný text záznamu