Manipulating Hippocampal Place Cell Activity by Single-Cell Stimulation in Freely Moving Mice
| Autor: | Maria Diamantaki, Patricia Preston-Ferrer, Philipp Berens, Khaled Nasr, Andrea Burgalossi, Sophie Laturnus, R Zeraati, Stefano Coletta |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Neurons Computer science Movement Place cell Spatial Behavior Stimulation Stimulus (physiology) Hippocampal formation Hippocampus General Biochemistry Genetics and Molecular Biology Mice Inbred C57BL 03 medical and health sciences Mice 030104 developmental biology 0302 clinical medicine lcsh:Biology (General) Animals Cell stimulation Episodic memory Neuroscience lcsh:QH301-705.5 Evoked Potentials 030217 neurology & neurosurgery |
| Zdroj: | Cell Reports Cell Reports, Vol 23, Iss 1, Pp 32-38 (2018) |
| ISSN: | 2211-1247 |
| Popis: | Summary: Learning critically depends on the ability to rapidly form and store non-overlapping representations of the external world. In line with their postulated role in episodic memory, hippocampal place cells can undergo a rapid reorganization of their firing fields upon contextual manipulations. To explore the mechanisms underlying such global remapping, we juxtacellularly stimulated 42 hippocampal neurons in freely moving mice during spatial exploration. We found that evoking spike trains in silent neurons was sufficient for creating place fields, while in place cells, juxtacellular stimulation induced a rapid remapping of their place fields to the stimulus location. The occurrence of complex spikes was most predictive of place field plasticity. Our data thus indicate that plasticity-inducing stimuli are able to rapidly bias place cell activity, simultaneously suppressing existing place fields. We propose that such competitive place field dynamics could support the orthogonalization of the hippocampal map during global remapping. : Place cells can serve as a readout of hippocampal memory. Diamantaki et al. show that the activity of single place cells can be rapidly modified by single-cell stimulation in freely moving mice. This finding provides insights into the cellular mechanisms that support the rapid reorganization of hippocampal place maps. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|