No-carrier-added 123I-MIBG: An initial clinical study in patients with phaeochromocytoma
| Autor: | J. B. Neilly, Robert J. Mairs, N. S. Reed, J. Prosser, S. H. Cunningham, A. A. Bolster, T. E. Hilditch, J Owens |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Drug Chemistry Pharmaceutical media_common.quotation_subject No carrier added Adrenal Gland Neoplasms Pheochromocytoma Pharmacology Iodine Radioisotopes Clinical study Humans Medicine Radiology Nuclear Medicine and imaging In patient Patient group media_common Tomography Emission-Computed Single-Photon 123i mibg business.industry General Medicine Middle Aged Drug accumulation 3-Iodobenzylguanidine Female Specific activity Radiopharmaceuticals business |
| Zdroj: | Nuclear Medicine Communications. 21:437-440 |
| ISSN: | 0143-3636 |
| DOI: | 10.1097/00006231-200005000-00005 |
| Popis: | Radioiodinated meta-iodobenzylguanidine (MIBG) is used routinely for imaging and targeted radiotherapy of tumours derived from the neural crest. Since active uptake of MIBG by the noradrenaline transporter (NAT) makes a greater contribution to total drug accumulation than passive uptake when MIBG is present at low concentrations, tumour-specific uptake should be enhanced by the administration of lower molar amounts of MIBG. This could be achieved through the use of MIBG with a high specific activity. Commercially available preparations of 123I-MIBG have specific activities of approximately 200 MBq.mg-1. We have synthesized and used no-carrier-added (n.c.a.) 123I-MIBG produced by an iododesilylation reaction (specific activity 0.7 TBq.mg-1). We report here the first clinical studies comparing the commercially available and n.c.a. MIBG diagnostic preparations. Five patients with known phaeochromocytoma were studied. Unlike studies in animal models, no consistent improvement in tumour uptake was observed with the n.c.a. material. A larger patient group is required to determine whether there are significant differences between the two preparations, before proceeding to studies at therapeutic activity levels of n.c.a. 131I-MIBG. Even with no improvement in tumour uptake, n.c.a. MIBG may be the favoured formulation for therapeutic applications to reduce the molar amount of drug injected. |
| Databáze: | OpenAIRE |
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