An Expedient Four Component Synthesis of Substituted Pyrido-Pyrimidine Heterocycles in Glycerol:Proline Based Low Transition Temperature Mixture and Their Antioxidant Activity with Molecular Docking Studies
| Autor: | Jai S. Ghosh, Madhukar B. Deshmukh, Prafulla B. Choudhari, Priyanka P. Mohire, Dattatray Chandam, Vishram Karande, Ajinkya A. Patravale |
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| Rok vydání: | 2020 |
| Předmět: |
Green chemistry
Barbituric acid Antioxidant Polymers and Plastics Four component Pyrimidine 010405 organic chemistry medicine.medical_treatment Transition temperature Organic Chemistry 010402 general chemistry 01 natural sciences 0104 chemical sciences chemistry.chemical_compound chemistry Materials Chemistry medicine Glycerol Organic chemistry Proline human activities |
| Zdroj: | Polycyclic Aromatic Compounds. 42:137-155 |
| ISSN: | 1563-5333 1040-6638 |
| Popis: | The present work describes an efficient and environmentally benign four component synthesis of structurally diverse substituted pyrido-pyrimidines involving the reaction of barbituric acid, 4-hydroxy 6-methyl 2-pyrone, an aromatic aldehyde and ammonium acetate in low transition temperature mixture (LTTM) (glycerol:proline: 1:1). The LTTM serves as green solvent which is an inexpensive, nontoxic and plays a dual function (reusable catalyst and solvent), and is found to be an excellent reaction endorsing medium. The present protocol offers some advantages such as easy work up, shorter reaction time, an excellent yield with higher atom economy, maximum reaction efficiency with an excellent green chemistry metrics. The synthesized compounds have been evaluated for their antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay as well as molecular docking studies performed on myeloperoxidase enzyme. Tested scaffolds exhibits an excellent results of virtual screening and antioxidant activity. |
| Databáze: | OpenAIRE |
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