Normal pressure hydrocephalus associated with COVID-19 infection: a case report

Autor: Moysés Loiola Ponte de Souza, Paulo Ribeiro Nóbrega, Pedro Braga-Neto, Manoel Alves Sobreira Neto, Glauber de Menezes Ferreira, Alander Sobreira Vanderlei, Thaís de Maria Frota Vasconcelos, José Daniel Vieira de Castro
Rok vydání: 2022
Předmět:
Zdroj: BMC Infectious Diseases. 22
ISSN: 1471-2334
DOI: 10.1186/s12879-022-07184-x
Popis: Background COVID-19 is a pandemic disease responsible for many deaths worldwide. Many neurological manifestations have been described. We report a case of normal pressure hydrocephalus (NPH) 2 months after acute COVID19 infection, in a patient without other risk factors. Case presentation A 45-year-old male patient presented an 8-month history of progressive gait disorder and cognitive impairment after being hospitalized for SARS-CoV-2 infection. Magnetic resonance imaging (MRI) was compatible with NPH. A spinal tap test was positive and there was progressive improvement after shunting, with complete resolution of symptoms. Conclusion Other infections such as syphilis, cryptococcosis and Lyme disease have been associated with NPH. Possible mechanisms for NPH after COVID include disruption of choroid plexus cells by direct viral invasion or as a result of neuroinflammation and cytokine release and hypercoagulability leading to venous congestion and abnormalities of CSF flow. Given the significance of NPH as a cause of reversible dementia, it is important to consider the possibility of a causal association with COVID19 and understand the mechanisms behind this association.
Databáze: OpenAIRE
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