A Randomized Trial Comparing Seven-Day Ranitidine Bismuth Citrate and Clarithromycin Dual Therapy to Seven-Day Omeprazole, Clarithromycin and Amoxicillin Triple Therapy for the Eradication of Helicobacter pylori
| Autor: | Lorinda Simms, Alan Barkun, Barbara Nicholls, Alan Cockeram, Alain Farley, Carlo A Fallone, Chrystian Dallaire, Naoki Chiba, Sander Veldhuyzen van Zanten |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Time Factors macromolecular substances Ranitidine Gastroenterology Drug Administration Schedule law.invention Helicobacter Infections Pharmacotherapy Randomized controlled trial law Internal medicine Clarithromycin polycyclic compounds Medicine Humans Urea lcsh:RC799-869 Omeprazole biology Helicobacter pylori business.industry Amoxicillin General Medicine Middle Aged biochemical phenomena metabolism and nutrition biology.organism_classification Anti-Ulcer Agents bacterial infections and mycoses eye diseases Anti-Bacterial Agents Breath Tests Patient Satisfaction Ranitidine Hydrochloride Drug Therapy Combination Female lcsh:Diseases of the digestive system. Gastroenterology business Bismuth medicine.drug |
| Zdroj: | Canadian Journal of Gastroenterology, Vol 17, Iss 9, Pp 533-538 (2003) |
| ISSN: | 0835-7900 |
| Popis: | OBJECTIVE: To assessHelicobacter pylorieradication after one week dual ranitidine bismuth citrate-clarithromycin (RBC-C) or triple omeprazole, clarithromycin and amoxicillin (OCA) therapy.METHODS: In this multicentre Canadian trial,H pylori-positive patients with functional dyspepsia or inactive peptic ulcer disease were randomized to open-label treatment with RBC-C (ranitidine bismuth citrate 400 mg plus clarithromycin 500 mg) or OCA (omezaprole 20 mg, clarithromycin 500 mg and amoxicillin 1000 mg), given twice a day for seven days. Treatment allocation was randomly assigned.H pyloriinfection was confirmed by positive13C-urea breath test (13C-UBT).H pyloristatus was reassessed by UBT at least four and 12 weeks after treatment (negative: δ13CO2below 3.5 per mil). Intention-to-treat (ITT) eradication rates were determined for all patients with confirmedH pyloriinfection. Per protocol (PP) rate was determined for all patients treated with at least two evaluable follow-up visits.RESULTS: Three hundred five patients were included in the ITT and 222 in the PP analysis. The ITT eradication rates were 66% for RBC-C and 78% for OCA. The PP success rates were 84% for RBC-C and 96% for OCA. The difference for both ITT 12% (95% CI 2 to 22) and PP 12% (95% CI 4 to 19) were statistically significant, P=0.030 and P=0.007, respectively. Treatment was generally well tolerated.CONCLUSION: The eradication rate for the seven-day dual RBC-C regimen was lower than that for OCA. |
| Databáze: | OpenAIRE |
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