Lipoprotein-associated phospholipase A2 predicts lower limb ischemia in hemodialysis subjects
Autor: | Andreana De Mauri, Matteo Vidali, Umberto Dianzani, Doriana Chiarinotti, Roberta Rolla |
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Rok vydání: | 2019 |
Předmět: |
Male
medicine.medical_specialty Multivariate analysis Apolipoprotein B medicine.medical_treatment Population 030232 urology & nephrology 030204 cardiovascular system & hematology Risk Assessment 03 medical and health sciences Peripheral Arterial Disease 0302 clinical medicine Phospholipase A2 Ischemia Renal Dialysis Diabetes mellitus Internal medicine medicine Prevalence Humans education Aged education.field_of_study Leg biology business.industry Lipoprotein-associated phospholipase A2 Hematology Middle Aged medicine.disease Peripheral Nephrology 1-Alkyl-2-acetylglycerophosphocholine Esterase biology.protein Cardiology lipids (amino acids peptides and proteins) Female Hemodialysis business |
Zdroj: | Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis TherapyREFERENCES. 24(5) |
ISSN: | 1744-9987 |
Popis: | Hemodialyzed patients (HD) have high prevalence of peripheral arterial disease. In the general population, lipoprotein-associated phospholipase A2 (Lp-PLA2 ) is associated with peripheral arterial disease but no data are available for renal subjects. The aim of this study was to evaluate the relationship between Lp-PLA2 and lower limb ischemia among dialyzed patients. One hundred and two dialyzed subjects, with median (IQR) age of 71 (59-78) years, enrolled in June 2013 and followed until June 2018, were investigated for Lp-PLA2 activity and the occurrence of peripheral arterial disease and lower limb ischemia. The median (IQR) levels of Lp-PLA2 were 184 nmol/min/mL (156.5-214.5). The 43 HD patients with abnormal Lp-PLA2 activity (>194 nmol/min/mL) had higher levels of total and LDL-cholesterol, ApoB/A1 ratio, and higher occurrence of lower limb ischemia during the follow up (44% vs 17%, P = .003). In multivariate analysis, Lp-PLA2 activity (P = .018) and diabetes (P < .001) were independently associated with time to lower limb ischemia, and when the presence of previous PAD was added to the multivariate model, only presence of previous PAD (P < .001) and Lp-PLA2 (P = .003) remained associated. Lp-PLA2 is an independent predictor of lower limb ischemia in dialyzed patients. |
Databáze: | OpenAIRE |
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