Nitrilimine cycloadditions to MeOPEG-bounded alkenyl dipolarophiles

Autor:	Giorgio Molteni, Luisa Garanti, Pietro Angelo Casati
Rok vydání:	2002
Předmět:	chemistry.chemical_compound Enantiopure drug chemistry Nitrilimine Acrylamide medicine Organic chemistry Basic hydrolysis Chloride Medicinal chemistry Cycloaddition medicine.drug
Zdroj:	Scopus-Elsevier
ISSN:	1364-5463 1472-7781
DOI:	10.1039/b206629g
Popis:	Base treatment of hydrazonoyl chloride 2 with MeOPEG-supported acrylates 1 and acrylamides 5 gave the corresponding MeOPEG-supported 4,5-dihydropyrazoles 3 and 6. Basic hydrolysis of the cycloadducts caused the removal of the MeOPEG pendant giving 5-carboxy- or 5-aminocarbonyl-4,5-dihydropyrazoles 7 and 8, respectively. Cycloaddition between 2 and enantiopure MeOPEG-supported acrylamide 10 gave a mixture of MeOPEG-supported cycloadducts 11 and 12 with low diastereoselectivity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3d73410e77c0d3a87eac13256769b2 https://doi.org/10.1039/b206629g Zobrazit plný text záznamu