Link betweenHelicobacter pylori-associated gastritis and duodenal ulcer
| Autor: | Sanae Teramura, Jung Kenn Yoo, Youji Takahashi, Motonobu Murakami, Toru Kita, Hiroshi Saita, Hiroshi Dekigai |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Aging medicine.medical_specialty Duodenum Physiology digestive system Gastroenterology Helicobacter Infections Internal medicine medicine Gastric mucosa Humans Antrum Gastric Acidity Determination Gastric Juice Helicobacter pylori biology business.industry Stomach digestive oral and skin physiology Middle Aged biology.organism_classification digestive system diseases medicine.anatomical_structure Gastric Mucosa Duodenal Ulcer Gastritis Gastric acid Atrophy medicine.symptom business |
| Zdroj: | Digestive Diseases and Sciences. 38:117-122 |
| ISSN: | 1573-2568 0163-2116 |
| DOI: | 10.1007/bf01296782 |
| Popis: | We examined the interrelationships among the degree of fundic mucosal atrophy, the prevalence of Helicobacter pylori in the gastric antrum, the gastric juice, and the duodenum with and without gastric metaplasia, in 20 duodenal ulcer patients and 20 non-duodenal ulcer patients. The detection rates of H. pylori in the antrum, the gastric juice, and the duodenum were significantly higher in duodenal ulcer patients (80%, 65%, and 60%) than in non-duodenal ulcer subjects (50%, 20%, and 5%). The frequency of H. pylori was significantly lower in the gastric juice (30%) and the duodenum (10%) in non-duodenal ulcer patients with antral H. pylori, compared with those in duodenal ulcer patients with antral H. pylori. All of seven patients with both gastric metaplasia and H. pylori infection in the duodenum had duodenal ulcer, whereas only 1 of 14 patients without either gastric metaplasia or H. pylori infection in the duodenum had duodenal ulcer. There was normal or mild atrophic mucosa in the fundus of duodenal ulcer patients with H. pylori in the antrum, whereas moderate or severe atrophic mucosa in non-duodenal ulcer patients with H. pylori gastritis. These results suggest that the preserved fundic mucosa, gastric metaplasia in the duodenum, and a greater load of H. pylori to the duodenum through the gastric juice may be prerequisites for the formation of duodenal ulcers. |
| Databáze: | OpenAIRE |
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