Contribution of the Axon Initial Segment to Action Potentials Recorded Extracellularly
| Autor: | Romain Brette, Alain Destexhe, Maria Teleńczuk, Bartosz Telenczuk |
|---|---|
| Přispěvatelé: | Unité de Neurosciences Information et Complexité [Gif sur Yvette] (UNIC), Centre National de la Recherche Scientifique (CNRS), Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Institut de la Vision, Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2018 |
| Předmět: |
MESH: Rats
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology education Models Neurological computational modelling Action Potentials Neuronal Excitability Sodium Channels axon initial segment MESH: Sodium Channels 03 medical and health sciences 0302 clinical medicine MESH: Models Neurological Extracellular medicine Animals MESH: Animals MESH: Electrophysiological Phenomena Axon MESH: Axon Initial Segment MESH: Action Potentials 030304 developmental biology Physics 0303 health sciences [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior Pyramidal Cells [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences extracellular action potential MESH: Pyramidal Cells New Research Axon initial segment Action (physics) Electrophysiological Phenomena Rats Electrophysiology Dipole medicine.anatomical_structure nervous system 6.1 Soma Neuron Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | eNeuro eNeuro, Society for Neuroscience, 2018, 5 (3), pp.ENEURO.0068-18.2018. ⟨10.1523/ENEURO.0068-18.2018⟩ eneuro |
| ISSN: | 2373-2822 |
| DOI: | 10.1523/ENEURO.0068-18.2018⟩ |
| Popis: | Action potentials (APs) are electric phenomena that are recorded both intracellularly and extracellularly. APs are usually initiated in the short segment of the axon called the axon initial segment (AIS). It was recently proposed that at onset of an AP the soma and the AIS form a dipole. We study the extracellular signature (the extracellular action potential, EAP) generated by such a dipole. First, we demonstrate the formation of the dipole and its extracellular signature in detailed morphological models of a reconstructed pyramidal neuron. Then, we study the EAP waveform and its spatial dependence in models with axonal AP initiation and contrast it with the EAP obtained in models with somatic AP initiation. We show that in the models with axonal AP initiation the dipole forms between somatodendritic compartments and the AIS, and not between soma and dendrites as in the classical models. Soma-dendrites dipole is present only in models with somatic AP initiation. Our study has consequences for interpreting extracellular recordings of single-neuron activity and determining electrophysiological neuron types, but also for better understanding the origins of the high-frequency macroscopic electric fields recorded in the brain.New & NoteworthyWe studied the consequences of the action potential (AP) initiation site on the extracellular signatures of APs. We show that: (1) at the time of AP initiation the action initial segment (AIS) forms a dipole with the soma, (2) the width but not (3) amplitude of the extracellular AP generated by this dipole increases with the soma-AIS distance. This may help to monitor dynamic changes in the AIS position in experimental in vivo recordings. |
| Databáze: | OpenAIRE |
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