Serum Thioredoxin 1 Level Has Close Relation with Myocardial Damage Amount in Acute Myocardial Infarction Patients
| Autor: | Sang Yeub Lee, Yeon-Jeong Kim, Sang Min Kim, Myeong Chan Cho, Young Kwang Shim, Jeong Tae Kim, Jang-Whan Bae, Mun-Hyuk Seong, Dong Woon Kim, Ki-Seok Kim, Kyung-Kuk Hwang, Tae-Jin Shim |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Cardiovascular Disorders medicine.medical_treatment Myocardial Infarction Coronary Angiography medicine.disease_cause Biochemical Markers Percutaneous Coronary Intervention Thioredoxins Troponin T Troponin complex Internal medicine medicine Creatine Kinase MB Form Humans ST segment Myocardial infarction Creatine Kinase Aged biology business.industry Myocardium Percutaneous coronary intervention General Medicine Middle Aged medicine.disease Oxidative Stress medicine.anatomical_structure Echocardiography Acute Disease Cardiology biology.protein Female Original Article Creatine kinase business Biomarkers Oxidative stress Artery |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1598-6357 1011-8934 |
| DOI: | 10.3346/jkms.2012.27.10.1162 |
| Popis: | Thioredoxin-1 (Trx-1) is one of important anti-oxidative molecules to overcome the oxidative stress. The aim of the present study is to investigate the clinical relationship between serum concentration of Trx-1 on the pre-percutaneous coronary intervention (prePCI) and myocardial damage amount in the patients with acute myocardial infarction with the culprit lesion in only the left anterior descending artery on coronary angiography (n = 100). Initial value of creatine kinase (CK) was 368.3 ± 531.4 U/L, and MB isoenzyme of CK (CK-MB) level was 22.92 ± 33.8 ng/mL, and cardiac specific troponin T (cTnT) level was 0.61 ± 1.6 ng/mL. Positive correlations were observed between prePCI Trx-1 level and initial CK (P = 0.005, r = 0.281), and cTnT (P < 0.001, r = 0.453), peak CK (P = 0.001, r = 0.316) in all patients, but the statistical relation was observed only in ST segment elevation myocardial infarction (STEMI) patients (P = 0.008, r = 0.329 for initial CK, P = 0.001, r = 0.498 for initial cTnT, P = 0.005, r = 0.349 for peak CK), not in Non-STEMI patients. Conclusively, we consider prePCI serum Trx-1 as a predictor for myocardial damage amount in patients with STEMI. |
| Databáze: | OpenAIRE |
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