Effect of Vitamin D Supplementation on Glycemic Control in Patients With Type 2 Diabetes (SUNNY Trial): A Randomized Placebo-Controlled Trial
| Autor: | Yvonne H M Krul-Poel, Frank Stam, Paul Lips, Suat Simsek, Hans van Wijland, Sanne Westra, Edwin ten Boekel, Marieke M. ter Wee, Natasja M. van Schoor |
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| Přispěvatelé: | Rheumatology, Epidemiology and Data Science, Internal medicine, EMGO - Lifestyle, overweight and diabetes, EMGO+ - Lifestyle, Overweight and Diabetes |
| Rok vydání: | 2015 |
| Předmět: |
Vitamin
Blood Glucose Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Placebo-controlled study Type 2 diabetes Placebo Gastroenterology chemistry.chemical_compound Insulin resistance SDG 3 - Good Health and Well-being Double-Blind Method Internal medicine Diabetes mellitus Internal Medicine medicine Vitamin D and neurology Humans Hypoglycemic Agents Vitamin D Glycemic Aged Advanced and Specialized Nursing business.industry Middle Aged medicine.disease Endocrinology chemistry Diabetes Mellitus Type 2 Dietary Supplements Female business |
| Zdroj: | Krul-Poel, Y H M, Westra, S, ten Boekel, E, ter Wee, M M, van Schoor, N M, van Wijland, H, Stam, F, Lips, P T A M & Simsek, S 2015, ' Effect of Vitamin D Supplementation on Glycemic Control in Patients With Type 2 Diabetes (SUNNY Trial): A Randomized Placebo-Controlled Trial ', Diabetes Care, vol. 38, no. 8, pp. 1420-1426 . https://doi.org/10.2337/dc15-0323 Diabetes Care, 38(8), 1420-1426. American Diabetes Association Inc. |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/dc15-0323 |
| Popis: | OBJECTIVE Low vitamin D status has been associated with impaired glycemic control in patients with type 2 diabetes. The purpose of our study was to evaluate the effect of vitamin D supplementation on glycemic control in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS This randomized, double-blind, placebo-controlled trial was conducted in 275 adult patients with type 2 diabetes without insulin treatment. Patients were randomly assigned to receive either vitamin D3 (50,000 IU/month) or placebo for 6 months. To assess the primary outcome of the study, change in HbA1c, we performed a linear regression analysis. RESULTS Mean baseline serum 25-hydroxyvitamin D [25(OH)D] increased from 60.6 ± 23.3 to 101.4 ± 27.6 nmol/L and 59.1 ± 23.2 to 59.8 ± 23.2 nmol/L in the vitamin D and placebo group, respectively. Mean baseline HbA1c was 6.8 ± 0.5% (51 ± 6 mmol/mol) in both groups. After 6 months, no effect was seen on HbA1c (mean difference: β = 0.4 [95% CI −0.6 to 1.5]; P = 0.42) and other indicators of glycemic control (HOMA of insulin resistance, fasting insulin, and glucose) in the entire study population. Subgroup analysis in patients with a serum 25(OH)D 7% (53 mmol/mol) did not differ the results. CONCLUSIONS In a well-controlled group of patients with type 2 diabetes, intermittent high-dose vitamin D supplementation did not improve glycemic control. |
| Databáze: | OpenAIRE |
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