Desempenho hemodinâmico e resposta inflamatória durante o uso do DAV-InCor como ponte para o transplante
| Autor: | Noedir Antônio Groppo Stolf, Anderson Benício, João Galantier, Fernando Bacal, E A Bocchi, Idágene A. Cestari, Luiz Felipe P. Moreira, Adolfo A. Leirner |
|---|---|
| Jazyk: | portugalština |
| Rok vydání: | 2008 |
| Předmět: |
Heart transplantation
medicine.medical_specialty circulação assistida/métodos business.industry medicine.medical_treatment Cardiogenic shock Hemodynamics Transplante cardíaco/mortalidade medicine.disease Surgery coração artificial/tendências Transplantation Ventricular assist device Internal medicine Circulatory system Idiopathic dilated cardiomyopathy medicine Cardiology coração auxiliar/utilização Cardiology and Cardiovascular Medicine business Perfusion |
| Zdroj: | Arquivos Brasileiros de Cardiologia v.91 n.5 2008 Arquivos Brasileiros de Cardiologia Sociedade Brasileira de Cardiologia (SBC) instacron:SBC |
| Popis: | BACKGROUND: Cardiac transplantation faces the serious problem of lack of donors and it is estimated that 20 to 40% of the patients die while waiting for heart transplantation. For these patients, the use of mechanical circulatory assist devices is the only choice of survival while waiting for a donor. In Brazil, the experience with mechanical circulatory support is limited and there is no regular program regarding the use of these devices as a bridge to heart transplantation. OBJECTIVE: To evaluate the hemodynamic performance and the systemic inflammatory response during the clinical use of the InCor-type ventricular assist device (VAD-InCor) as a bridge to heart transplantation. METHODS: Between October 2003 and April 2006, 11 patients in the waiting list for heart transplantation presented hemodynamic deterioration due to refractory cardiogenic shock. Seven of these patients were submitted to VAD-InCor implantation for left ventricular assistance. The etiologic diagnosis was Chagas' disease in 5 patients and idiopathic dilated cardiomyopathy in 2. RESULTS: The duration of left ventricular assistance ranged from 14 to 42 days (mean 26.2 days). During this period, the hemodynamic performance of the DAV-InCor was adequate to support a normal hemodynamic state. There was normalization of central venous oxygen saturation and serum lactate. Two patients were submitted to heart transplantation, while the other 5 patients died under assistance due to infection and multiple organ failure. CONCLUSION: The performance of the VAD-InCor, in the hemodynamic behavior of the studied patients, was adequate for the maintenance of a satisfactory circulatory state during the studied period. There was improvement in the tissue perfusion parameters and maintenance of systemic inflammatory response signs. There was a high incidence of complications; however, complications related to the device, which could compromise the safety of its use, were not demonstrated. |
| Databáze: | OpenAIRE |
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