The neutrophil–lymphocyte ratio and locoregional melanoma: a multicentre cohort study
| Autor: | D Dewar, Michelle C. I. Lo, Alyss V. Robinson, Ryckie G. Wade, Marc Moncrieff, Claire Keeble, Owen Thornton, Howard Peach |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Skin Neoplasms Neutrophils Neutrophil–lymphocyte ratio Immunology Sentinel lymph node Kaplan-Meier Estimate Cohort Studies Leukocyte Count 03 medical and health sciences 0302 clinical medicine Recurrence Internal medicine Humans Immunology and Allergy Medicine Lymphocytes Platelet–lymphocyte ratio Stage (cooking) Melanoma Aged Neoplasm Staging 030304 developmental biology Aged 80 and over 0303 health sciences business.industry Proportional hazards model fungi Biomarker Odds ratio Middle Aged Sentinel node medicine.disease Lymphatic Metastasis 030220 oncology & carcinogenesis Cutaneous melanoma Female Original Article business Lymphocyte–monocyte ratio Cohort study |
| Zdroj: | Cancer Immunology, Immunotherapy |
| ISSN: | 1432-0851 0340-7004 |
| DOI: | 10.1007/s00262-019-02478-7 |
| Popis: | Objectives The neutrophil–lymphocyte ratio (NLR) is an inflammatory biomarker which is useful in cancer prognostication. We aimed to investigate the differences in baseline NLR between patients with localised and metastatic cutaneous melanoma and how this biomarker changed over time with the recurrence of disease. Methods This multicentre cohort study describes patients treated for Stage I–III cutaneous melanoma over 10 years. The baseline NLR was measured immediately prior to surgery and again at the time of discharge or disease recurrence. The odds ratios (OR) for sentinel node involvement are estimated using mixed-effects logistic regression. The risk of recurrence is estimated using multivariable Cox regression. Results Overall 1489 individuals were included. The mean baseline NLR was higher in patients with palpable nodal disease compared to those with microscopic nodal or localised disease (2.8 versus 2.4 and 2.3, respectively; p Conclusion The NLR is associated with the volume of melanoma at presentation and may predict occult sentinel lymph metastases. Further prospective work is required to investigate how NLR may be modelled against other clinicopathological variables to predict outcomes and to understand the temporal changes in NLR following surgery for melanoma. |
| Databáze: | OpenAIRE |
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