Impact of Glycolipid Hydrophobic Chain Length and Headgroup Size on Self-Assembly and Hydrophobic Guest Release
| Autor: | Rati Ranjan Nayak, Kanaparedu P. C. Sekhar, Harikrishna Adicherla |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
02 engineering and technology
010402 general chemistry 01 natural sciences Micelle chemistry.chemical_compound Drug Delivery Systems Glycolipid Electrochemistry General Materials Science Coloring Agents Micelles Spectroscopy Alkyl chemistry.chemical_classification Drug Carriers Solvatochromism Surfaces and Interfaces Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Condensed Matter Physics 0104 chemical sciences Hydrophobe Chemical engineering chemistry Drug delivery Pyrene lipids (amino acids peptides and proteins) Self-assembly Glycolipids 0210 nano-technology Hydrophobic and Hydrophilic Interactions |
| Zdroj: | Langmuir. 34:8875-8886 |
| ISSN: | 1520-5827 0743-7463 |
| Popis: | Encapsulation of a hydrophobic guest molecule inside a micelle and its stimuli-sensitive release is a useful strategy for target-specific drug delivery. Herein, nine biobased glycolipids were derived from plant sources. The influence of headgroup on the stability and aggregation pattern in water with different alkyl chain lengths was investigated to deduce the structure-property relationship. External factors, such as temperature, pH, and NaCl and urea concentrations, were employed to explore stimuli response of glycolipid nanoassemblies. Furthermore, solvatochromic dyes, such as pyrene, N-phenyl-1-naphthylamine, and curcumin, were utilized to examine hydrophobe loading capacities of these glycolipid assemblies. A fluorescence study was performed to investigate the enzyme-sensitive hydrophobe release. Interestingly, the pH-sensitive hydrophobic guests showed pH-responsive release from dynamic micelles. Finally, the synthesized glycolipids revealed their nanoassemblies as smart carriers for hydrophobic cargo. |
| Databáze: | OpenAIRE |
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