Helper T cell differentiation
| Autor: | Nicole M. Chapman, Hongbo Chi, Jordy Saravia |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Systems biology Immunology Review Article Disease Adaptive Immunity Cell fate determination Biology 03 medical and health sciences 0302 clinical medicine Animals Humans Immunology and Allergy Cell Lineage Gene Regulatory Networks Helper T cell differentiation Cellular metabolism Transcriptional Networks Cell Differentiation T-Lymphocytes Helper-Inducer Acquired immune system Important research 030104 developmental biology Infectious Diseases Cytokines Neuroscience 030215 immunology |
| Zdroj: | Cell Mol Immunol |
| ISSN: | 2042-0226 1672-7681 |
| DOI: | 10.1038/s41423-019-0220-6 |
| Popis: | CD4(+) T helper cells are key regulators of host health and disease. In the original model, specialized subsets of T helper cells are generated following activation through lineage-specifying cytokines and transcriptional programs, but recent studies have revealed increasing complexities for CD4(+) T-cell differentiation. Here, we first discuss CD4(+) T-cell differentiation from a historical perspective by highlighting the major studies that defined the distinct subsets of T helper cells. We next describe the mechanisms underlying CD4(+) T-cell differentiation, including cytokine-induced signaling and transcriptional networks. We then review current and emerging topics of differentiation, including the plasticity and heterogeneity of T cells, the tissue-specific effects, and the influence of cellular metabolism on cell fate decisions. Importantly, recent advances in cutting-edge approaches, especially systems biology tools, have contributed to new concepts and mechanisms underlying T-cell differentiation and will likely continue to advance this important research area of adaptive immunity. |
| Databáze: | OpenAIRE |
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