Association of apolipoprotein (Apo)E genotype with plasma apo E levels
| Autor: | Giso Feussner, Ernst J. Schaefer, James R. Barnard, Carl DeLuca, Ilona A. Larson, Jose M. Ordovas |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Blood Glucose Male Apolipoprotein E Heterozygote medicine.medical_specialty Genotype Apolipoprotein B Apolipoprotein E4 chemistry.chemical_compound Apolipoproteins E Gene Frequency Internal medicine Blood plasma medicine Humans Allele frequency Alleles Aged Sex Characteristics biology Triglyceride Chemistry Cholesterol Cholesterol HDL Cholesterol LDL Middle Aged Endocrinology biology.protein Female lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine Lipoprotein |
| Zdroj: | Atherosclerosis. 148:327-335 |
| ISSN: | 0021-9150 |
| Popis: | The purpose of this study was to investigate the effects of apolipoprotein (apo) E genotype on plasma apo E levels as well as serum total, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglyceride, and glucose values in 734 middle-aged and elderly, female and male subjects. Apo E allele frequencies were similar to those reported in other Caucasian populations. After adjustment for medications, alcohol use, smoking, age, and body mass index, apo E genotype was noted to have significant effects on apo E, total cholesterol, LDL cholesterol, and glucose levels in females, and on apo E, LDL cholesterol, and HDL cholesterol levels, as well as the total cholesterol (TC)/HDL cholesterol ratio in males. Female and male subjects with the apo E4 allele had significantly (P |
| Databáze: | OpenAIRE |
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