Reductant-Free Aerobic Hydroxylation of Isoquinoline-1,3(2 H,4 H)-dione Derivatives

Autor:	Shuiying Wan, Lei Tang, Ying-Xian Li, Yuanhu Mao, Lin Zhang, Guo Yang, Yuan-Yong Yang, Yong-Long Zhao, Chun Li, Ji-Quan Zhang, Cheng Cheng
Rok vydání:	2019
Předmět:	chemistry.chemical_classification 010405 organic chemistry Tetrahydroisoquinoline Aryl Organic Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences Hydroxylation chemistry.chemical_compound chemistry Isoquinoline Alkyl
Zdroj:	The Journal of organic chemistry. 84(4)
ISSN:	1520-6904
Popis:	Base-catalyzed efficient hydroxylation of isoquinoline-1,3(2 H,4 H)-diones with air under transition-metal-free and reductant-free conditions was established. This methodology is essentially mild and compatible with a broad range of substrates, including aryl, heteroaryl, and alkyl groups. Also, the product could be simply transformed into a hydroxylated tetrahydroisoquinoline core structure through a reductive process.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ec89dc0022094f0ed60962190a5c1e https://pubmed.ncbi.nlm.nih.gov/30642180 Zobrazit plný text záznamu