Republished paper: Meta-analysis of the effect of comprehensive smoke-free legislation on acute coronary events
| Autor: | Daniel F. Mackay, Sally Haw, Jill P. Pell, M O Irfan |
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| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Postgraduate Medical Journal. 87:311-316 |
| ISSN: | 1469-0756 0032-5473 |
| DOI: | 10.1136/pgmj.2010.199026rep |
| Popis: | Objective To assess the evidence for a reduced risk of acute coronary events following comprehensive smoke-free legislation. Methods Two independent systematic reviews were undertaken using PubMed, Embase and Science Direct with no date restrictions imposed. Meta-analysis was undertaken using a random effects model to obtain a pooled estimate of the relative risk. Linear regression was used to examine possible bias and meta-regression was used to investigate possible causes of heterogeneity. Main outcome measure Acute coronary events. Results The 17 eligible studies (10 from North America, 6 from Europe and 1 from Australasia) provided 35 estimates of effect size. Apart from five subgroup analyses, all of the published results suggested a reduction in the incidence of acute coronary events following the introduction of smoke-free legislation. Meta-analysis produced a pooled estimate of the relative risk of 0.90 (95% CI 0.86 to 0.94). There was significant heterogeneity (overall I2=95.1%, p Conclusions There is now a large body of evidence supporting a reduction in acute coronary events following the implementation of comprehensive smoke-free legislation, with the effect increasing over time from implementation. Countries that have not yet adopted smoke-free legislation should be encouraged to do so. |
| Databáze: | OpenAIRE |
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