The effect of the placental DROSHA rs10719 and rs6877842 polymorphisms on PE susceptibility and mRNA expression
| Autor: | Abbas Mohammadpour-Gharehbagh, Darya Najafi, Mojgan Mokhtari, Mehrnaz Narooei-Nejad, Minoo Yaghmaei, Mahnaz Rezaei, Saeedeh Salimi, Mehrnaz Mehrabani, Batool Teimoori |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Ribonuclease III Heterozygote Placenta Blood Pressure 030204 cardiovascular system & hematology Polymorphism Single Nucleotide Risk Assessment Preeclampsia Pathogenesis Andrology Young Adult 03 medical and health sciences 0302 clinical medicine Gene Frequency Pre-Eclampsia Pregnancy Risk Factors Genotype Internal Medicine medicine Humans Genetic Predisposition to Disease 030212 general & internal medicine Allele Genotyping Drosha business.industry Homozygote Haplotype medicine.disease Phenotype medicine.anatomical_structure Haplotypes Case-Control Studies Female business |
| Zdroj: | Journal of Human Hypertension. 33:552-558 |
| ISSN: | 1476-5527 0950-9240 |
| Popis: | Evidence showed that microRNA biosynthesis plays the main role in pathogenesis of several diseases including Preeclampsia (PE). Therefore, microRNA processing enzymes may involve in PE predisposition. The aim of the present study was to evaluate the relation between DROSHA rs10719 and rs6877842 polymorphisms and mRNA expression in the placenta of PE women and controls. This study recruited 110 PE women and 115 age matched normotensive pregnant women for genotyping of DROSHA polymorphisms and analyzing of mRNA expression. There was no association between alleles and genotypes of placental DROSHA rs10719 and rs6877842 polymorphisms and PE susceptibility. However, placental DROSHA rs10719 was associated with increased PE risk in the recessive model. The combination of CC/GG genotypes of DROSHA rs10719 and rs6877842 polymorphisms was associated with higher risk of PE. The frequency of C-G haplotype was higher in PE women, but the difference was not significant. The DROSHA mRNA expression was downregulated in the placenta of PE women. There was no relation between DROSHA mRNA expression and rs6877842 polymorphism, however, it was decreased in the placenta of women with rs10719CC genotype. The placental DROSHA rs10719 but not rs6877842 polymorphism could be a risk factor for PE susceptibility only in the recessive model. The combination of CC/GG genotypes could be risk factors for PE susceptibility. The DROSHA expression downregulated in the preeclamptic placentas and those carrying rs10719CC genotype. |
| Databáze: | OpenAIRE |
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