Recent advances of dendrimer in targeted delivery of drugs and genes to stem cells as cellular vehicles
| Autor: | Ezzat Hashemi, Maryam Hashemi, Fatemeh Oroojalian, Zahra Salmasi, Elham Pishavar |
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| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
Drug Dendrimers media_common.quotation_subject Stem Cells 010401 analytical chemistry Gene Transfer Techniques Transfection Genetic Therapy Gene delivery Biology 01 natural sciences Regenerative medicine 0104 chemical sciences Cell biology Pharmaceutical Preparations 010608 biotechnology Dendrimer Drug delivery Stem cell Gene Biotechnology media_common |
| Zdroj: | Biotechnology progressREFERENCES. 37(4) |
| ISSN: | 1520-6033 |
| Popis: | Stem cells can be used to repair dysfunctional and injured (or cancerous) tissues by delivering therapeutics. However, in comparison with other cells, it is harder to transfect drugs or genes into stem cells. Dendrimers have been considered as efficient vectors to deliver both genes and drugs to stem cells due to their unique properties including adjustable molecular weight and size, low toxicity, high loading capacity, and having multiple peripheral chemical agents which can be functionalized to improve deliverance efficiency. In this review, we discuss dendrimer-mediated drug and gene delivery to stem cells as cellular vehicles and the role of this strategy in treating a variety of disorders via regenerative medicine approaches. |
| Databáze: | OpenAIRE |
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