Wernicke's encephalopathy
| Autor: | Nicholas A. Vick, Nathan K. Blank, Sidney Schulman |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Pathology
medicine.medical_specialty Encephalopathy Striatum Pathology and Forensic Medicine Wernicke's encephalopathy Lesion Necrosis Cellular and Molecular Neuroscience Myelin medicine Neuropil Animals Wernicke Encephalopathy Myelin Sheath Chemistry Thiamine Deficiency medicine.disease Macaca mulatta Axons Corpus Striatum Capillaries Mitochondria Disease Models Animal medicine.anatomical_structure nervous system Astrocytes Vacuoles Ultrastructure Thiamine Neurology (clinical) medicine.symptom Brain Stem Demyelinating Diseases |
| Zdroj: | Acta Neuropathologica. 31:137-150 |
| ISSN: | 1432-0533 0001-6322 |
| DOI: | 10.1007/bf00688148 |
| Popis: | Experimental Wernicke's encephalopathy, induced in rhesus monkeys with a diet lacking thiamine (vitamin B1), is characterized by cavitary necrosis of the striatum as well as a microvacuolar periventricular lesion of the brain stem such as occurs in man. With high resolution light microscopy and electron microscopy, the primary structural alteration in the brain stem lesion, and probably also in the striatum, appears to be that of widespread "blister" formation due to splitting of myelin at the intraperiod line. Microvascular alterations were minimal, even in the most severely affected regions. It is the myelin blisters which give rise to the spongy texture of the neuropil. A similar splitting of myelin has been described in several other experimental encephalopathies, and it is probable that it also occurs in Wernicke's encephalopathy in man. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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