Mapping risk factors for depression across the lifespan: An umbrella review of evidence from meta-analyses and Mendelian randomization studies
| Autor: | Matias Ca Melo, André F. Carvalho, Brendon Stubbs, Marco Solmi, Lazaros Belbasis, Brisa Simoes Fernandes, Mark Olfson, Evangelos Evangelou, Cristiano A. Köhler, Beatrice Bortolato, John P. A. Ioannidis, Nicola Veronese, Camila A Coelho |
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| Přispěvatelé: | Köhler, C.A., Evangelou, E., Stubbs, B., Solmi, M., Veronese, N., Belbasis, L., Bortolato, B., Melo, M.C.A., Coelho, C.A., Fernandes, B.S., Olfson, M., Ioannidis, J.P.A., Carvalho, A.F. |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
MOOD DISORDERS
PUBLISHED LITERATURE Longevity PsycINFO Risk Assessment 17 Psychology And Cognitive Sciences 03 medical and health sciences Umbrella review 0302 clinical medicine Mendelian randomization IMPAIRED GLUCOSE-METABOLISM medicine Humans OLDER-ADULTS Biological Psychiatry Depression (differential diagnoses) Psychiatry Science & Technology business.industry Depression Prevention genetic risk factor Prediction interval MAJOR DEPRESSION 11 Medical And Health Sciences Mendelian Randomization Analysis medicine.disease ADEQUATE PARENTAL CARE Mental health Confidence interval ADULT DEPRESSION 030227 psychiatry Meta-analyses Risk factors SYSTEMATIC REVIEWS Psychiatry and Mental health Systematic review Mood disorders INDIVIDUAL PARTICIPANT DATA business Life Sciences & Biomedicine MENTAL-HEALTH 030217 neurology & neurosurgery Demography |
| Zdroj: | Köhler, C A, Evangelou, E, Stubbs, B, Solmi, M, Veronese, N, Belbasis, L, Bortolato, B, Melo, M C A, Coelho, C A, Fernandes, B S, Olfson, M, Ioannidis, J P A & Carvalho, A F 2018, ' Mapping risk factors for depression across the lifespan : An umbrella review of evidence from meta-analyses and Mendelian randomization studies ', Journal of psychiatric research . https://doi.org/10.1016/j.jpsychires.2018.05.020 |
| Popis: | The development of depression may involve a complex interplay of environmental and genetic risk factors. PubMed and PsycInfo databases were searched from inception through August 3, 2017, to identify meta-analyses and Mendelian randomization (MR) studies of environmental risk factors associated with depression. For each eligible meta-analysis, we estimated the summary effect size and its 95% confidence interval (CI) by random-effects modeling, the 95% prediction interval, heterogeneity with I 2 , and evidence of small-study effects and excess significance bias. Seventy meta-analytic reviews met the eligibility criteria and provided 134 meta-analyses for associations from 1283 primary studies. While 109 associations were nominally significant (P < 0.05), only 8 met the criteria for convincing evidence and, when limited to prospective studies, convincing evidence was found in 6 (widowhood, physical abuse during childhood, obesity, having 4–5 metabolic risk factors, sexual dysfunction, job strain). In studies in which depression was assessed through a structured diagnostic interview, only associations with widowhood, job strain, and being a Gulf War veteran were supported by convincing evidence. Additionally, 8 MR studies were included and provided no consistent evidence for the causal effects of obesity, smoking, and alcohol consumption. The proportion of variance explained by genetic risk factors was extremely small (0.1–0.4%), which limited the evidence provided by the MR studies. Our findings suggest that despite the large number of putative risk factors investigated in the literature, few associations were supported by robust evidence. The current findings may have clinical and research implications for the early identification of individuals at risk for depression. © 2018 Elsevier Ltd |
| Databáze: | OpenAIRE |
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