Protection of immunized and previously infected chimpanzees challenged with Mycoplasma pneumoniae
| Autor: | Bobby Brown, Kaity Kapatais-Zoumbois, Donna K. F. Chandler, Ping-Chuan Hu, Michael F. Barile, Marion W. Grabowski |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
Mycoplasma pneumoniae Pan troglodytes Immunoglobulins Mycoplasmataceae medicine.disease_cause Pneumonia Mycoplasma medicine Animals Colonization Immunization Schedule General Veterinary General Immunology and Microbiology biology Public Health Environmental and Occupational Health biology.organism_classification medicine.disease Virology Pharyngitis Pneumonia Infectious Diseases Immunization Vaccines Inactivated Immunology Bacterial Vaccines Mollicutes biology.protein Molecular Medicine medicine.symptom Antibody Bronchoalveolar Lavage Fluid |
| Zdroj: | Vaccine. 12(8) |
| ISSN: | 0264-410X |
| Popis: | Following immunization, peak geometric mean serum metabolism inhibition antibody (MIT) titres were 1:13 and 1:16 for groups of three chimpanzees each that received either the formalin-inactivated OSU-1A or experimental acellular extract vaccine, respectively. Following challenge, the mean titres for chimpanzees given the acellular vaccine peaked at 1:256 in 4 weeks and was 1:48 at 10 weeks. Chimpanzees given the OSU-1A vaccine peaked at 1:80 in 4 weeks and remained at 1:80 at 10 weeks. There was no direct correlation between the serum MIT response and the severity of disease or colonization, and thus the MIT response was not a reliable measurement of protection. The two non-immunized chimpanzees showed significant signs of disease, including cough, pharyngitis, rhinitis, fever and abnormal X-ray findings, for about 5 weeks. The chimpanzees immunized with either vaccine were less colonized and showed far less disease than non-immunized controls. Protection afforded the chimpanzees was similar to that of vaccinees in the human clinical trial given the same OSU-1A vaccine (Wenzel et al., 1977). The two previously infected chimpanzees were most protected against colonization and disease on challenge. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|