Camptocormia as a clinical manifestation of polymyositis/systemic sclerosis overlap myositis associated with anti-Ku
| Autor: | Nathalie Streichenberger, Marie Puget, Thierry Zenone |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Pathology medicine.medical_specialty Movement disorders Immunology Polymyositis Spinal Curvatures Scleroderma Muscular Atrophy Spinal Camptocormia Rheumatology Internal medicine medicine Humans Immunology and Allergy Ku Autoantigen Myositis Aged Autoantibodies Scleroderma Systemic business.industry Antigens Nuclear Sclerodactyly medicine.disease DNA-Binding Proteins medicine.symptom business Rhabdomyolysis |
| Zdroj: | Rheumatology International. 33:2411-2415 |
| ISSN: | 1437-160X 0172-8172 |
| DOI: | 10.1007/s00296-012-2412-6 |
| Popis: | Camptocormia, an abnormal truncal flexion posture that occurs while walking or standing, is usually caused by various hypokinetic movement disorders, mainly Parkinson disease. We describe the case of a man with subacute onset of camptocormia. Quadriceps muscle biopsy showed significant rhabdomyolysis, few isolated inflammatory cells and mild expression of type I MHC in few fibers, a pattern usually found in immune-mediated necrotizing myopathies. Myositis was associated with Raynaud's phenomenon, mild sclerodactyly, and anti-Ku antibodies leading to the diagnosis of polymyositis/systemic sclerosis overlap myositis. The posture showed modest improvement in response to treatment. |
| Databáze: | OpenAIRE |
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