Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment

Autor: Leah Burns, Remko de Jong, Magdalini Tsolaki, Frans R.J. Verhey, Lutz Frölich, Ronald A. van Schijndel, Daniel Rueckert, Philip Scheltens, Frederik Barkhof, Dirk L. Knol, Flavio Nobili, Robin Wolz, Pieter Jelle Visser, Harald Hampel, Pablo Lapuerta, Hilkka Soininen, Lars Olaf Wahlund, Ineke van Rossum, Lies Clerx, Martina Bocchetta, Laura A. van de Pol, Lennart Minthon, Pauline Aalten
Přispěvatelé: Neuroscience Campus Amsterdam - Neurodegeneration, Neurology, Epidemiology and Data Science, Radiology and nuclear medicine, NCA - neurodegeneration, Promovendi MHN, Psychiatrie & Neuropsychologie, MUMC+: MA Med Staf Spec Psychiatrie (9), RS: MHeNs School for Mental Health and Neuroscience
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Male
Aging
Pathology
Neurology
Hippocampal formation
Corpus callosum
Hippocampus
030218 nuclear medicine & medical imaging
Aβ1-42
Alzheimer's disease
Cerebrospinal fluid (CSF)
Dementia
Magnetic resonance imaging
Medial temporal lobe atrophy
Mild cognitive impairment
Tau
Aged
Alzheimer Disease
Amyloid beta-Peptides
Atrophy
Biomarkers
Cognition
Disease Progression
Female
Forecasting
Humans
Magnetic Resonance Imaging
Mild Cognitive Impairment
Peptide Fragments
tau Proteins
Neurology (clinical)
Neuroscience (all)
Developmental Biology
Geriatrics and Gerontology
0302 clinical medicine
Cognitive decline
General Neuroscience
Cardiology
Aβ1–42
Psychology
medicine.medical_specialty
Neuroscience(all)
Clinical Neurology
Temporal lobe
03 medical and health sciences
Internal medicine
medicine
Cognitive Dysfunction
Receiver operating characteristic
medicine.disease
Ageing
A beta 1-42
030217 neurology & neurosurgery
Zdroj: Neurobiology of Aging, 34(8), 2003-2013. Elsevier Inc.
Clerx, L, van Rossum, I A, Burns, L, Knol, D L, Scheltens, P, Verhey, F, Aalten, P, Lapuerta, P, van de Pol, L A, van Schijndel, R A, Jong, R, Barkhof, F, Wolz, R, Rueckert, D, Bocchetta, M, Tsolaki, M, Nobili, F, Wahlund, L O, Minthon, L, Frolich, L, Hampel, H, Soininen, H & Visser, P J 2013, ' Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment ', Neurobiology of Aging, vol. 34, no. 8, pp. 2003-2013 . https://doi.org/10.1016/j.neurobiolaging.2013.02.002
Neurobiology of Aging, 34(8), 2003-2013. Elsevier Science
ISSN: 0197-4580
DOI: 10.1016/j.neurobiolaging.2013.02.002
Popis: Our aim was to compare the predictive accuracy of 4 different medial temporal lobe measurements for Alzheimer's disease (AD) in subjects with mild cognitive impairment (MCI). Manual hippocampal measurement, automated atlas-based hippocampal measurement, a visual rating scale (MTA-score), and lateral ventricle measurement were compared. Predictive accuracy for AD 2 years after baseline was assessed by receiver operating characteristics analyses with area under the curve as outcome. Annual cognitive decline was assessed by slope analyses up to 5 years after baseline. Correlations with biomarkers in cerebrospinal fluid (CSF) were investigated. Subjects with MCI were selected from the Development of Screening Guidelines and Clinical Criteria for Predementia AD (DESCRIPA) multicenter study (n = 156) and the single-center VU medical center (n = 172). At follow-up, area under the curve was highest for automated atlas-based hippocampal measurement (0.71) and manual hippocampal measurement (0.71), and lower for MTA-score (0.65) and lateral ventricle (0.60). Slope analysis yielded similar results. Hippocampal measurements correlated with CSF total tau and phosphorylated tau, not with beta-amyloid 1-42. MTA-score and lateral ventricle volume correlated with CSF beta-amyloid 1-42. We can conclude that volumetric hippocampal measurements are the best predictors of AD conversion in subjects with MCI. (c) 2013 Elsevier Inc. All rights reserved. (Less)
Databáze: OpenAIRE
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