Exozómy zo synoviálnej tekutiny ako zdroj potenciálnych biomarkerov osteoartritídy / Synovial fluid-derived exosomes as a source of potential biomarkers of osteoarthritis

Autor: Morávek, Marko, Rosocha, Ján, Špaková, Tímea
Jazyk: slovenština
Rok vydání: 2022
Předmět:
ISSN: 1359-1371
DOI: 10.5281/zenodo.6457526
Popis: Súhrn Osteoartritída je degeneratívne ochorenie pohybového aparátu trápiace milióny ľudí po celom svete. Preto je výskum v oblasti správnej diagnostiky a efektívnej liečby osteoartritídy veľkou celospoločenskou objednávkou. Exozómy ako extracelulárne produkty buniek s obsahom nukleových kyselín, proteínov a lipidov spĺňajú, okrem iného, aj úlohu medzibunkovej komunikácie a ovplyvňujú biologickú aktivitu buniek. Táto práca sa venuje popisu patogenézy osteoartritídy a biogenézy, zloženia a funkcie exozómov asociovaných s týmto degeneratívnym ochorením. Skúmanie funkcie exozómov pri osteoartritíde pomôže objasniť patogenézu a preskúmať nové potenciálne biomarkery tohto ochorenia. Abstract Osteoarthritis is a degenerative disease of the musculoskeletal system affecting millions of people around the world. Therefore, research focusing on the correct diagnosis and effective treatment of osteoarthritis represents a major society-wide order. Exosomes as extracellular products of cells containing nucleic acids, proteins and lipids fulfill the role of intercellular communication and affect the biological activity of cells. This article describes the pathogenesis of osteoarthritis and the biogenesis, composition and function of exosomes associated with this degenerative disease. Investigation of exosomes function in osteoarthritis will help to elucidate the pathogenesis and investigate other new potential biomarkers of this disease.
Táto publikácia vznikla vďaka podpore v rámci operačného programu Integrovaná infraštruktúra pre projekt Otvorená vedecká komunita pre moderný interdisciplinárny výskum v medicíne (OPENMED), kód ITMS2014+: 313011V455, spolufinancovaný zo zdrojov Európskeho fondu regionálneho rozvoja a vďaka Agentúre na podporu výskumu a vývoja na základe zmluvy č. APVV-17-0118. This publication is the result of support under the Operational Program Integrated Infrastructure for the project Open Scientific Community for Advanced Interdisciplinary Research in Medicine (OPENMED), code ITMS2014 +: 313011V455, co-financed by the European Regional Development Fund and the Agency for Research and Development under contract no. APVV-17-0118.
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Databáze: OpenAIRE
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