Influence of Nitric Oxide Synthase and Adrenergic Inhibition on Adenosine-Induced Myocardial Hyperemia
| Autor: | Morten Bøttcher, Michael J. Mulvany, Flemming Hermansen, Niels H. Buus, Torsten Toftegaard Nielsen, Mikael Sander |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Adenosine Myocardium/metabolism Adrenergic alpha-Antagonists/pharmacology Coronary Vessels/diagnostic imaging Adrenergic Hemodynamics Blood Pressure Vasodilation Phentolamine/pharmacology chemistry.chemical_compound Heart Rate Adenosine/pharmacology Enzyme Inhibitors Enzyme Inhibitors/pharmacology Heart Rate/drug effects Hyperemia/chemically induced Heart Coronary Vessels Perfusion NG-Nitroarginine Methyl Ester medicine.anatomical_structure Anesthesia Coronary Circulation/drug effects Cardiology and Cardiovascular Medicine Tomography Emission-Computed medicine.drug Adult Endothelium Vascular/drug effects medicine.medical_specialty Endothelium Nitric Oxide Synthase/antagonists & inhibitors Hyperemia Arginine Nitric Oxide Blood Pressure/drug effects Receptors adrenergic alpha Nitric oxide Phentolamine Coronary Circulation Physiology (medical) Internal medicine medicine Humans NG-Nitroarginine Methyl Ester/pharmacology Adrenergic alpha-Antagonists business.industry Nitric Oxide/biosynthesis Microcirculation Myocardium Vasodilation/drug effects Vascular Resistance/drug effects Heart/drug effects Microcirculation/drug effects Endocrinology chemistry Vascular Resistance Endothelium Vascular Nitric Oxide Synthase business Arginine/pharmacology |
| Zdroj: | Buus, N H, Bøttcher, M, Hermansen, F, Sander, M, Nielsen, T T & Mulvany, M J 2001, ' Influence of nitric oxide synthase and adrenergic inhibition on adenosine-induced myocardial hyperemia ', Circulation, vol. 104, no. 19, pp. 2305-2310 . Buus, N H, Bøttcher, M, Hermansen, F, Sander, M, Nielsen, T T & Mulvany, M J 2001, ' Influence of nitric oxide synthase and adrenergic inhibition on adenosine-induced myocardial hyperemia ', Circulation, vol. 104, no. 19, pp. 2305-2310 . https://doi.org/10.1161/hc4401.098293 Buus, N H, Bøttcher, M, Hermansen, F, Sander, M, Nielsen, T T & Mulvany, M J 2001, ' Influence of nitric oxide synthase and adrenergic inhibition on adenosine-induced myocardial hyperemia ', Circulation, vol. 104, no. 19, pp. 2305-10 . https://doi.org/10.1161/hc4401.098293 Buus, N H, Bøttcher, M, Hermansen, F, Sander, M, Nielsen, T T & Mulvany, M J 2001, ' Influence of nitric oxide synthase and adrenergic inhibition on adenosine-induced myocardial hyperemia ', Circulation, vol. 104, no. 19, pp. 2305-2310 . https://doi.org/10.1161/hc4401.098293, https://doi.org/10.1161/hc4401.098293 Aarhus University |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/hc4401.098293 |
| Popis: | Background Myocardial perfusion during adenosine-induced hyperemia is used both in clinical diagnosis of coronary heart disease and for scientific investigations of the myocardial microcirculation. The objective of this study was to clarify whether adenosine-induced hyperemia is dependent on endothelial NO production or is influenced by adrenergic mechanisms. Methods and Results In 12 healthy men, myocardial perfusion was measured with PET in 2 protocols performed in random order, each including 3 perfusion measurements. First, perfusion was measured at rest. Second, either saline or the NO synthase inhibitor N G -nitro- l -arginine methyl ester (L-NAME, 4 mg/kg) was infused, and perfusion during adenosine-induced hyperemia was determined. Last, in both protocols, the α-receptor blocker phentolamine was infused, and perfusion during adenosine-induced hyperemia was determined again. Resting perfusion was similar in the 2 protocols (0.69±0.14 and 0.66±0.18 mL · min −1 · g −1 ). L-NAME increased mean arterial blood pressure by 12±7 mm Hg ( P P −1 · g −1 ) was attenuated by L-NAME (1.50±0.55 mL · min −1 · g −1 , P −1 · g −1 , P =NS). In the presence of L-NAME, however, when the adenosine response was attenuated, phentolamine was able to increase hyperemic perfusion (2.05±0.44 mL · min −1 · g −1 , P Conclusions Inhibition of endogenous NO synthesis attenuates myocardial perfusion during adenosine-induced hyperemia, indicating that coronary vasodilation by adenosine is partly endothelium dependent. α-Adrenergic blockade has no effect on adenosine-induced hyperemia unless NO synthesis is inhibited. |
| Databáze: | OpenAIRE |
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