Effects of hormonal contraceptives on dry eye disease: a population-based study
| Autor: | Abbas Kezouh, Alfonso Iovieno, Sonia N. Yeung, Mahyar Etminan, Bonnie He |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Lifitegrast Adolescent Disease Article 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Contraceptive Agents Risk Factors medicine Odds Ratio Humans Risk factor Medical prescription Retrospective Studies business.industry Confounding Retrospective cohort study Odds ratio Middle Aged Population based study Ophthalmology chemistry 030221 ophthalmology & optometry Dry Eye Syndromes Female business 030217 neurology & neurosurgery |
| Zdroj: | Eye (Lond) |
| ISSN: | 1476-5454 |
| Popis: | Background Hormonal contraceptives (HCs) are a known risk factor for dry eye disease (DED), yet the relationship between HCs use and DED in women of child-bearing age remains debatable. The aim of this study was to determine the association between HCs and DED in females of reproductive age. Methods This was a retrospective cohort study using data from IQVIA's electronic medical record (IQVIA, USA). 4,871,504 women (age 15-45) between 2008 and 2018 were followed to the first diagnosis of DED as defined by an ICD-9/10 code. DED cases also required at least two prescriptions of cyclosporine or lifitegrast topical drops within 60 days of the first code. The date of the first code was designated as the index date. Regular HCs users needed to have at least two prescriptions in both the first year and second year prior to the index date. For each case, five controls were selected and matched to cases by age and follow-up time. A conditional logistic regression model was used to adjust for confounders of DED and to calculate odds ratios (ORs). Results HCs users were at a higher risk for DED than non-users. Regular users of HCs were more likely to develop DED (ORs = 2.73, 95% CI [2.21-3.73]) than irregular users. Those who used a greater number of HCs were at a higher risk for DED. Conclusions This study indicates an increased risk of DED with HCs use in women of child-bearing age. |
| Databáze: | OpenAIRE |
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