Diaryl ether inhibitors of farnesyl-protein transferase

Autor:	Joseph P. Davide, Robert B. Lobell, Kelly Hamilton, Kenneth S. Koblan, Ronald G. Robinson, Nancy E. Kohl, S. Jane Desolms, Samuel L. Graham, S. C. Mactough, John H. Hutchinson, Anthony W. Shaw, Terrence M. Ciccarone, Marc Abrams
Rok vydání:	2001
Předmět:	Farnesyl Protein Transferase Clinical Biochemistry Pharmaceutical Science Ether Binding Competitive Biochemistry Chemical synthesis Cell Line Inhibitory Concentration 50 Structure-Activity Relationship chemistry.chemical_compound Peptide Library Nucleophilic aromatic substitution Drug Discovery Animals Transferase Organic chemistry Enzyme Inhibitors Molecular Biology chemistry.chemical_classification Farnesyl-diphosphate farnesyltransferase Alkyl and Aryl Transferases biology Chemistry Phenyl Ethers Organic Chemistry Imidazoles Rats Enzyme Enzyme inhibitor biology.protein Molecular Medicine
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 11:1257-1260
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(01)00162-7
Popis:	Imidazolemethyl diaryl ethers are potent inhibitors of farnesyl-protein transferase. The SNAr displacement reaction used to prepare these diaryl ethers was amenable to rapid parallel synthesis of FPTase inhibitors. The use of a broad range of commercially available phenols quickly identified compounds which proved active in cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a97313784c223cafc9cb62933fc9a131 https://doi.org/10.1016/s0960-894x(01)00162-7 Zobrazit plný text záznamu Full Text from ScienceDirect