Acute Effects of Oral Dehydroepiandrosterone on Counterregulatory Responses During Repeated Hypoglycemia in Healthy Humans
| Autor: | Nino G. Joy, Maia Mikeladze, Maka S. Hedrington, Lisa M. Younk, Ian Davis, Donna B. Tate, Stephen N. Davis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Blood Glucose Male medicine.medical_specialty Complications Endocrinology Diabetes and Metabolism Dehydroepiandrosterone Administration Oral 030209 endocrinology & metabolism Hypoglycemia Placebo Glucagon Drug Administration Schedule 03 medical and health sciences Norepinephrine 0302 clinical medicine Internal medicine Internal Medicine medicine Humans Single-Blind Method Pure autonomic failure business.industry medicine.disease Healthy Volunteers Autonomic nervous system 030104 developmental biology Epinephrine Endocrinology Female business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Diabetes |
| ISSN: | 1939-327X 0012-1797 |
| Popis: | We tested the hypothesis that acute administration of oral dehydroepiandrosterone (DHEA) during episodes of repeated hypoglycemia can prevent the development of hypoglycemia-associated neuroendocrine and autonomic failure in healthy humans. Twenty-seven individuals (16 men, 11 women) participated in two separate randomized, single-blind, 2-day protocols. Day 1 consisted of morning and afternoon 2-h hypoglycemic clamps (2.9 mmol/L) with 800 mg of DHEA or placebo administered before each clamp. Day 2 consisted of a single 2-h hypoglycemic clamp (2.9 mmol/L) following either DHEA (1,600 mg) or placebo. A 3-tritiated glucose was used to determine glucose kinetics during hypoglycemia on day 2. Antecedent hypoglycemia with placebo resulted in significant reductions of epinephrine, norepinephrine, glucagon, growth hormone, cortisol, endogenous glucose production, and lipolytic and symptom responses. During hypoglycemia on day 2, DHEA prevented blunting of all neuroendocrine, autonomic nervous system (ANS), metabolic, and symptom counterregulatory responses following hypoglycemia on day 1. In summary, DHEA can acutely preserve a wide range of key neuroendocrine, ANS, and metabolic counterregulatory homeostatic responses during repeated hypoglycemia. We conclude that DHEA may have acute effects to protect against hypoglycemia-associated neuroendocrine and autonomic failure in healthy humans. |
| Databáze: | OpenAIRE |
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