Drosophila ALS Regulates Growth and Metabolism through Functional Interaction with Insulin-like Peptides
| Autor: | Charles Géminard, Pierre Léopold, Nathalie Arquier, Gisèle Jarretou, Alexandre Paix, Marc Bourouis, Basil Honegger |
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| Přispěvatelé: | Institut de signalisation, biologie du développement et cancer (ISBDC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Zoologisches Institut, Univ Zurich, Universität Zürich [Zürich] = University of Zurich (UZH), Laboratoire de Biologie du Développement de Villefranche sur mer (LBDV), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Observatoire océanologique de Villefranche-sur-mer (OOVM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Observatoire océanologique de Villefranche-sur-mer (OOVM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2008 |
| Předmět: |
MESH: Drosophila
Physiology medicine.medical_treatment HUMDISEASE MESH: Animal Nutrition Physiology MESH: Insulin-Like Growth Factor Binding Proteins 0302 clinical medicine [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB] Drosophila Proteins MESH: Animals media_common Genetics 0303 health sciences biology MESH: Energy Metabolism Longevity MESH: Gene Expression Regulation Insulin-Like Growth Factor Binding Proteins Biochemistry SIGNALING Larva 030220 oncology & carcinogenesis Animal Nutritional Physiological Phenomena Drosophila MESH: Drosophila Proteins media_common.quotation_subject Protein subunit Blotting Western MESH: Stress 03 medical and health sciences Somatomedins Stress Physiological medicine Animals MESH: Blotting Western Drosophila (subgenus) MESH: Somatomedins Molecular Biology 030304 developmental biology Growth factor Insulin Lipid metabolism Metabolism Cell Biology MESH: Multiprotein Complexes biology.organism_classification Insulin receptor Gene Expression Regulation Multiprotein Complexes biology.protein Energy Metabolism MESH: Larva 030217 neurology & neurosurgery Function (biology) |
| Zdroj: | Cell Metabolism Cell Metabolism, Elsevier, 2008, 7 (4), pp.333-8. ⟨10.1016/j.cmet.2008.02.003⟩ Cell Metabolism, 2008, 7 (4), pp.333-8. ⟨10.1016/j.cmet.2008.02.003⟩ |
| ISSN: | 1550-4131 |
| DOI: | 10.1016/j.cmet.2008.10.005 |
| Popis: | Summary In metazoans, factors of the insulin family control growth, metabolism, longevity, and fertility in response to environmental cues. In Drosophila , a family of seven insulin-like peptides, called Dilps, activate a common insulin receptor. Some Dilp peptides carry both metabolic and growth functions, raising the possibility that various binding partners specify their functions. Here we identify dALS, the fly ortholog of the vertebrate insulin-like growth factor (IGF)-binding protein acid-labile subunit (ALS), as a Dilp partner that forms a circulating trimeric complex with one molecule of Dilp and one molecule of Imp-L2, an IgG-family molecule distantly related to mammalian IGF-binding proteins (IGFBPs). We further show that dALS antagonizes Dilp function to control animal growth as well as carbohydrate and fat metabolism. These results lead us to propose an evolutionary perspective in which ALS function appeared prior to the separation between metabolic and growth effects that are associated with vertebrate insulin and IGFs. |
| Databáze: | OpenAIRE |
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