Analysis of the bone microRNome in osteoporotic fractures
| Autor: | Pablo Garmilla-Ezquerra, Manuel Sumillera, Jesus Delgado-Calle, José A. Riancho, Carolina Sañudo, María I. Pérez-Núñez |
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| Rok vydání: | 2014 |
| Předmět: |
Oncology
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Osteoporosis Bone and Bones Pathogenesis Endocrinology Quality of life Bone Density Internal medicine medicine Humans Orthopedics and Sports Medicine In patient Stage (cooking) Aged Aged 80 and over business.industry Hip Fractures medicine.disease Surgery Trabecular bone MicroRNAs Gene Expression Regulation Orthopedic surgery Osteoporotic bone Quality of Life Female business Osteoporotic Fractures |
| Zdroj: | Calcified tissue international. 96(1) |
| ISSN: | 1432-0827 |
| Popis: | Osteoporosis causes important morbidity among elderly individuals. Fragility fractures, and especially hip fractures, have a particularly negative impact on the patients’ quality of life. The role of epigenetic mechanisms in the pathogenesis of many disorders is increasingly recognized, yet little is known about their role in non-malignant bone disorders such as osteoporosis. The aim of this study was to explore the expression of miRNAs in patients with osteoporotic hip fractures. Trabecular bone samples were obtained from the femoral heads of patients undergoing replacement surgery for osteoporotic hip fractures and non-fracture controls with hip osteoarthritis. Levels of 760 miRNA were analyzed by real-time PCR. Thirteen miRNAs showed nominally significant (p |
| Databáze: | OpenAIRE |
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