miRNAs and SAMHD1 regulation in vitro and in a model of HIV CNS disease

Autor:	Erin L. Buchanan, Stephanie L. Myers, Kenneth W. Witwer, Melissa A. McAlexander
Rok vydání:	2015
Předmět:	Microglia General Neuroscience Immunology Biology Simian biology.organism_classification Virology In vitro 3. Good health Cellular and Molecular Neuroscience medicine.anatomical_structure Neurology In vivo microRNA Aspartic acid medicine Sterile alpha motif SAMHD1
Zdroj:	Journal of Neuroinflammation. 12
ISSN:	1742-2094
DOI:	10.1186/s12974-015-0380-y
Popis:	Pilakka-Kanthikeel et al. recently reported higher levels of the retroviral restriction factor sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) in astrocytes than in microglia, suggesting that SAMHD1 levels might explain in part the relatively refractory nature of astrocytes to retroviral replication. These findings are consistent with our studies of simian and human immunodeficiency virus infection of astrocytes and macrophages. Similarly, a role for two host microRNAs in post-transcriptional regulation of SAMHD1 agrees with our in vitro results and those of others. However, data from an animal model of HIV neurologic disorders may not be consistent with robust miRNA-mediated regulation of SAMHD1 in vivo.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a954566ec39607d40dc349f7ef744806 https://doi.org/10.1186/s12974-015-0380-y Zobrazit plný text záznamu Full text from SpringerLink