Comparative Study of the Immunohistochemical Phenotype in Breast Cancer and Its Lymph Node Metastatic Location

Autor:	Manuel Ruiz Borrego, Fernando López Rubio, Enrique Aranda Aguilar, Miguel A. Japón, Paulino Travado, Carlos Villar Pastor, Auxiliadora Gómez España, José Andrés Moreno Nogueira, Juan de la Haba-Rodriguez
Rok vydání:	2004
Předmět:	Cancer Research Pathology medicine.medical_specialty Receptor ErbB-2 Estrogen receptor Breast Neoplasms Breast cancer Progesterone receptor Humans Medicine Lymph node biology business.industry General Medicine medicine.disease Immunohistochemistry Phenotype Primary tumor Ki-67 Antigen medicine.anatomical_structure Receptors Estrogen Oncology Lymphatic Metastasis Ki-67 biology.protein Female Tumor Suppressor Protein p53 Receptors Progesterone business
Zdroj:	Cancer Investigation. 22:219-224
ISSN:	1532-4192 0735-7907
DOI:	10.1081/cnv-120030210
Popis:	At present, an important part of prognostic information, together with particular treatment strategies in breast cancer, take into account the immunohistochemical phenotype of the primary tumor location. However, the changing heterogeneity intrinsic to neoplastic cells in general leads us to consider the possibility that the expression of these proteins is modified during tumoral development and dissemination. With this hypothesis as a starting point, 60 patients with breast cancer were studied with immunohistochemistry, the expression of estrogen and progestagenic receptors, proliferation through the Ki-67 expression, and the overexpression of HER-2 and p53 in both the primary location and the lymph node metastases. If we consider significant change to be loss (from positive to negative) or gain (negative to positive) of expression in some of the studied determinations, we find that this is produced in 60% of the tumors studied. These results demonstrate the modification of immunohistochemical expression of the proteins studied between the primary tumor location and the lymph node metastases.
Databáze:	OpenAIRE
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