Antioxidant Effect ofSpirulina (Arthrospira) maximaon Chronic Inflammation Induced by Freund's Complete Adjuvant in Rats
| Autor: | Marcela Galar-Martínez, Germán Chamorro-Cevallos, Elizdath Martínez-Galero, Ana Gabriela Hernández-Reyes, Rosa Virginia García-Rodríguez, Gabriel Alfonso Gutiérrez-Rebolledo |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Antioxidant medicine.medical_treatment Freund's Adjuvant Anti-Inflammatory Agents Medicine (miscellaneous) Inflammation Motor Activity Pharmacology Biology Protective Agents medicine.disease_cause Antioxidants Body Temperature Protein Carbonylation Lipid peroxidation chemistry.chemical_compound Leukocytes Spirulina medicine Animals Spirulina (dietary supplement) chemistry.chemical_classification Reactive oxygen species Nutrition and Dietetics Plant Extracts biology.organism_classification Arthritis Experimental Rats Oxidative Stress Treatment Outcome chemistry Freund's adjuvant Immunology Joints Lipid Peroxidation medicine.symptom Full Communications Reactive Oxygen Species Arthrospira Oxidative stress Phytotherapy |
| Zdroj: | Journal of Medicinal Food. 18:865-871 |
| ISSN: | 1557-7600 1096-620X |
| Popis: | One of the major mechanisms in the pathogenesis of chronic inflammation is the excessive production of reactive oxygen and reactive nitrogen species, and therefore, oxidative stress. Spirulina (Arthrospira) maxima has marked antioxidant activity in vivo and in vitro, as well as anti-inflammatory activity in certain experimental models, the latter activity being mediated probably by the antioxidant activity of this cyanobacterium. In the present study, chronic inflammation was induced through injection of Freund's complete adjuvant (CFA) in rats treated daily with Spirulina (Arthrospira) maxima for 2 weeks beginning on day 14. Joint diameter, body temperature, and motor capacity were assessed each week. On days 0 and 28, total and differential leukocyte counts and serum oxidative damage were determined, the latter by assessing lipid peroxidation and protein carbonyl content. At the end of the study, oxidative damage to joints was likewise evaluated. Results show that S. maxima favors increased mobility, as well as body temperature regulation, and a number of circulating leukocytes, lymphocytes, and monocytes in specimens with CFA-induced chronic inflammation and also protects against oxidative damage in joint tissue as well as serum. In conclusion, the protection afforded by S. maxima against development of chronic inflammation is due to its antioxidant activity. |
| Databáze: | OpenAIRE |
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