Effects of Intermittent Positive Pressure Ventilation on Cardiopulmonary Function in Horses Anesthetized with Total Intravenous Anesthesia Using Combination of Medetomidine, Lidocaine, Butorphanol and Propofol (MLBP-TIVA)
| Autor: | Tsukasa Nagaro, Takaharu Itami, Tadashi Sano, Kenjirou Miyoshi, Tomohito Ishizuka, Kanako Sudo, Jun Tamura, Mohammed Ahamed Umar, Kazuto Yamashita |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Cardiac output
Lidocaine Butorphanol Blood Pressure Intermittent Positive-Pressure Ventilation Heart Rate Heart rate medicine Animals Horses Cardiac Output Propofol cardiopulmonary function Cross-Over Studies Full Paper General Veterinary business.industry Oxygenation Carbon Dioxide Medetomidine intermittent positive pressure ventilation (IPPV) horse Oxygen Drug Combinations Blood pressure Anesthesia MLBP-TIVA Anesthesia Intravenous Surgery business medicine.drug |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 0916-7250 |
| Popis: | Effects of intermittent positive pressure ventilation (IPPV) on cardiopulmonary function were evaluated in horses anesthetized with total intravenous anesthesia using constant rate infusions of medetomidine (3.5 µg/kg/hr), lidocaine (3 mg/kg/hr), butorphanol (24 µg/kg/hr) and propofol (0.1 mg/kg/min) (MLBP-TIVA). Five horses were anesthetized twice using MLBP-TIVA with or without IPPV at 4-week interval (crossover study). In each occasion, the horses breathed 100% oxygen with spontaneous ventilation (SB-group, n=5) or with IPPV (CV-group, n=5), and changes in cardiopulmonary parameters were observed for 120 min. In the SB-group, cardiovascular parameters were maintained within acceptable ranges (heart rate: 33-35 beats/min, cardiac output: 27-30 l/min, mean arterial blood pressure [MABP]: 114-123 mmHg, mean pulmonary arterial pressure [MPAP]: 28-29 mmHg and mean right atrial pressure [MRAP]: 19-21 mmHg), but severe hypercapnea and insufficient oxygenation were observed (arterial CO(2) pressure [PaCO(2)]: 84-103 mmHg and arterial O(2) pressure [PaO(2)]: 155-172 mmHg). In the CV-group, normocapnea (PaCO(2): 42-50 mmHg) and good oxygenation (PaO(2): 395-419 mmHg) were achieved by the IPPV without apparent cardiovascular depression (heart rate: 29-31 beats/min, cardiac output: 17-21 l /min, MABP: 111-123 mmHg, MPAP: 27-30 mmHg and MRAP: 15-16 mmHg). MLBP-TIVA preserved cardiovascular function even in horses artificially ventilated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|