Iron accumulation in human spleen in autoimmune thrombocytopenia and hereditary spherocytosis
| Autor: | J. Jakubovsky, Mária Čaplovičová, P. Minoo, I. Zitnanova, A. Kopaniova, O. El-Hassoun, Paulína Gálfiová, V Sisovsky, S. Stvrtina, Cs. Biro, L. Kolenova, L. Guller, Martin Kopáni |
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| Rok vydání: | 2012 |
| Předmět: |
Economics and Econometrics
Antioxidant Glycoconjugate medicine.medical_treatment Spleen Spherocytosis Hereditary Haematoxylin Ferric Compounds Autoimmune thrombocytopenia Hereditary spherocytosis chemistry.chemical_compound Materials Chemistry Media Technology medicine Humans chemistry.chemical_classification Purpura Thrombocytopenic Idiopathic Reactive oxygen species Eosin Histocytochemistry Forestry medicine.disease Molecular biology medicine.anatomical_structure chemistry Reactive Oxygen Species Glycoconjugates |
| Zdroj: | Bratislava Medical Journal. 113:92-94 |
| ISSN: | 1336-0345 |
| Popis: | BACKGROUND Although the iron is an essential element for the physiological functions of cells, tissues and organs, it is also an important inductor of reactive oxygen species (ROS). MATERIAL AND METHODS Three groups of human spleen with autoimmune thrombocytopenia (AITP), hereditary spherocytosis (HS) and reference samples stained by haematoxylin and eosin, Perls' reaction for nonheme Fe(III) iron and Alcian blue for glycoconjugates detection were studied. RESULTS Positive Perls' reaction in both AITP and HS groups was seen. Higher positivity in the HS than in AITP group was observed. HS group showed a higher amount of acidic glycoconjugates deposits than AITP group. Iron overload in HS and AITP leads to overproduction of ROS. CONCLUSION We suggest that acidic glycoconjugates deposits are involved in antioxidant defence by elimination and restriction of iron as a ROS inducer (Fig. 4, Ref. 19). |
| Databáze: | OpenAIRE |
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