A core–shell structure QRu-PLGA-RES-DS NP nanocomposite with photothermal response-induced M2 macrophage polarization for rheumatoid arthritis therapy
| Autor: | Jie Liu, Guanglong Yuan, Xu Chen, Ange Lin, Youcong Gong, Litao Ma, Xufeng Zhu |
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| Rok vydání: | 2019 |
| Předmět: |
02 engineering and technology
Resveratrol 010402 general chemistry 01 natural sciences Ruthenium Nanocomposites Mice chemistry.chemical_compound Immune system In vivo Human Umbilical Vein Endothelial Cells Animals Humans General Materials Science Chemistry Macrophages Photothermal effect technology industry and agriculture Hyperthermia Induced Phototherapy Photothermal therapy 021001 nanoscience & nanotechnology 0104 chemical sciences PLGA RAW 264.7 Cells Cancer research Nanomedicine Rheumatic Fever Nanocarriers 0210 nano-technology Polyglycolic Acid |
| Zdroj: | Nanoscale. 11:18209-18223 |
| ISSN: | 2040-3372 2040-3364 |
| DOI: | 10.1039/c9nr05922a |
| Popis: | Rheumatoid arthritis (RA) is a degenerative joint disease caused by autoimmunity; for the effective treatment of RA while avoiding the side effects of conventional drugs, we have proposed a new therapeutic strategy to eliminate the inflammatory response in RA by regulating the immune system that promotes the transformation of M1-type macrophages to M2-type macrophages. Herein, we designed and synthesized a core-shell nanocomposite (QRu-PLGA-RES-DS NPs), which showed an effective therapeutic effect on RA by accurately inducing the polarization of M2 macrophages. In this system, the quadrilateral ruthenium nanoparticles (QRuNPs) with a photothermal effect were utilized as a core and the thermosensitive molecular poly (lactic-co-glycolic acid) (PLGA) modified with the targeted molecule dextran sulfate (DS) was employed as a shell. Then, the nanocarrier QRu-PLGA-DS NPs effectively improved the water solubility and targeting of resveratrol (RES) through self-assembly. Therefore, the QRu-PLGA-RES-DS NPs significantly enhanced the ability of RES to reverse the M1 type macrophages to the M2 type macrophages through an accurate release. In vivo experiments further demonstrated that the QRu-PLGA-RES-DS NPs could effectively accumulate in the lesion area with an exogenous stimulus, and this significantly enhanced the transformation of the M2 type macrophages and decreased the recruitment of the M1 type macrophages. Furthermore, the QRu-PLGA-RES-DS NPs effectively treated RA by eliminating the inflammatory response; in addition, photoacoustic imaging (PA) of the QRu NPs provided image guidance for the distribution and analysis of nanomedicine in inflammatory tissues. Hence, this therapeutic strategy promotes the biological applications of Ru-based nanoparticles in disease treatment. |
| Databáze: | OpenAIRE |
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