Canonical T cell receptor docking on peptide-MHC is essential for T cell signaling
| Autor: | Sachith D. Gunasinghe, Lukasz Wojciech, C. Farenc, Jasmine Li, Christopher Szeto, Xavier Y.X. Sng, Nicole L. La Gruta, Jamie Rossjohn, Claerwen M. Jones, Katharina Gaus, Stephanie Gras, Angela Nguyen, Jan Petersen, Chantelle Blyth, Pirooz Zareie, Brian D. Evavold, Nicholas R. J. Gascoigne, Jesica R. Jacobs, Alex J. Fulcher, Elizabeth Motunrayo Kolawole, Qianru Wei |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Models Molecular CD3 Complex Protein Conformation T cell CD8 Antigens Receptors Antigen T-Cell alpha-beta Epitopes T-Lymphocyte Plasma protein binding CD8-Positive T-Lymphocytes Major histocompatibility complex Lymphocyte Activation Epitope Major Histocompatibility Complex 03 medical and health sciences Mice 0302 clinical medicine Docking (dog) Orthomyxoviridae Infections medicine Animals Histocompatibility Antigen H-2D Multidisciplinary biology Chemistry T-cell receptor Nucleocapsid Proteins Peptide Fragments Cell biology Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Influenza A virus Lymphocyte Specific Protein Tyrosine Kinase p56(lck) biology.protein Female Signal transduction CD8 030215 immunology Protein Binding Signal Transduction |
| Zdroj: | Science (New York, N.Y.). 372(6546) |
| ISSN: | 1095-9203 |
| Popis: | Making sense of TCR–pMHC topology Most T cells use a T cell receptor (TCR) that recognizes major histocompatibility complex molecules bound to peptides (pMHCs) derived from both self- and foreign antigens. Although there is great variability in the interface because of the diversity of both partners, this interaction displays a canonical docking topology for reasons that remain contested. Zareie et al. tested an assortment of both canonical and reversed-polarity TCRs that were all specific for the same cognate pMHC-I bearing a peptide derived from influenza A virus (IAV) (see the Perspective by Horkova and Stepanek). The authors determined that docking topology was the primary driver of in vivo T cell activation and recruitment when mice were infected with IAV. The canonical topology was required for the formation of a functional signaling complex, suggesting that T cell signaling constraints dictate how TCR and pMHC meet. Science , abe9124, this issue p. eabe9124 ; see also abj2937, p. 1038 |
| Databáze: | OpenAIRE |
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