| Popis: |
Background:Hyperlipidemia is one of the factors that can trigger atherosclerosis which is characterized by abnormalities in lipid metabolism in the blood, especially increased LDL levels above normal. The increase in level of LDL stimulates the production of several cytokines that can affect the increase in acute phase proteins, especially fibrinogen. The presence of fibrinogen functions in increasing the Erytrocyte Sedimentation Rate (ESR) through its positive charge to neutralize the surface of erythrocytes. Prevention efforts to reduce ESR use herbal plants that do not have side effects, namely robusta coffee. Anti-inflammatory and antioxidant activity in robusta coffee is thought to be effective in reducing ESR through inhibition of cytokine production in the inflammatory response. Objective:This study aimed to determine differences in ESR values after administration of robusta coffee to hyperlipidemia rats. Methods:Fiveteen male Wistar rats were randomly divided into 3 research groups including the control group (K), the hyperlipidemia group (H), and the hyperlipidemia + coffee group (C). Induction of hyperlipidemia by feeding duck egg yolk and pork oil. The calculation of the ESR level uses the Westegreen method in mm/hour. Results and Conclusions:Robusta coffee can affect the decrease in ESR values in hyperlipidemia rats |
