Transcranial Direct Current Stimulation in Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis
| Autor: | David J. Anschel, Carlos Trenado, Rafael Vázquez Gregorio, Leon Morales-Quezada, Maricarmen Fernández-González Aragón, Flavio Hernández-González, Daniel San-Juan, Felipe Fregni, Dulce Anabel Espinoza López, Axel Hernandez Ruiz, Alejandro Alcaraz-Guzmán |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_treatment Biophysics Stimulation Placebo Transcranial Direct Current Stimulation Hippocampus lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine Double-Blind Method Mesial temporal lobe epilepsy (MTLE) medicine Humans Ictal Adverse effect lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Aged Hippocampal sclerosis Sclerosis Transcranial direct-current stimulation General Neuroscience Electroencephalography Middle Aged medicine.disease Transcranial direct current stimulation (tDCS) Clinical trial Hippocampal sclerosis (HS) 030104 developmental biology Epilepsy Temporal Lobe Anesthesia Relative risk Female Neurology (clinical) Psychology 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Brain Stimulation, Vol 10, Iss 1, Pp 28-35 (2017) |
| ISSN: | 1876-4754 |
| Popis: | Background: Transcranial direct current stimulation (tDCS) has been evaluated in medication refractory epilepsy patients. The results have been inconclusive and protocols have varied between studies. Objective: To evaluate the safety and efficacy of two protocols of tDCS in adult patients with mesial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS). Methods: This is a randomized placebo-controlled, double-blinded clinical trial, with 3 arms, 3 sessions, 5 sessions and placebo stimulation. Frequency of seizures (SZs), interictal epileptiform discharges (IEDs) and adverse effects (AEs) were registered before and after treatment, and at 30 and 60 days follow-up. Descriptive statistics, k-related samples, Friedman's test, and relative risk (RR) estimation were used for analysis. Results: We included twenty-eight subjects (3d n = 12, 5d n = 8, placebo n = 8), 16/28 (57%) men, age 37.8(±10.9) years old. There was a significant reduction of the frequency of SZs at one (p = 0.001) and two (p = 0.0001) months following cathodal tDCS compared to baseline in the 3 arms (p = 0.0001). The mean reduction of SZ frequency at two months in both active groups was significantly higher than placebo (−48% vs. −6.25%, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect