Extracellular vesicles in hepatology: Physiological role, involvement in pathogenesis, and therapeutic opportunities
| Autor: | Marc Liebana, Maria Azparren-Angulo, Juan M. Falcón-Pérez, Laia Abad-Jordà, Felix Royo, Bruno Brotons, Felipe Goñi-de-Cerio, Nicolò Manicardi, J. Berganza, Esperanza Gonzalez, Jordi Gracia-Sancho |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Context (language use) 610 Medicine & health Cell Communication Biology Exosomes Extracellular vesicles Pathogenesis Extracellular Vesicles 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine Internal medicine medicine Humans Pharmacology (medical) Pharmacology Liver Diseases Gastroenterology Hepatology Diagnostics EVs Liver disease Microvesicles Therapeutics Multicellular organism 030104 developmental biology 030220 oncology & carcinogenesis Neuroscience |
| Zdroj: | Azparren-Angulo, Maria; Royo, Felix; Gonzalez, Esperanza; Liebana, Marc; Brotons, Bruno; Berganza, Jesús; Goñi-de-Cerio, Felipe; Manicardi, Nicoló; Abad-Jordà, Laia; Gracia Sancho, Jorge; Falcon-Perez, Juan M (2021). Extracellular vesicles in hepatology: Physiological role, involvement in pathogenesis, and therapeutic opportunities. Pharmacology & therapeutics, 218, p. 107683. Elsevier 10.1016/j.pharmthera.2020.107683 |
| DOI: | 10.1016/j.pharmthera.2020.107683 |
| Popis: | Since the first descriptions of hepatocyte-released exosome-like vesicles in 2008, the number of publications describing Extracellular Vesicles (EVs) released by liver cells in the context of hepatic physiology and pathology has grown exponentially. This growing interest highlights both the importance that cell-to-cell communication has in the organization of multicellular organisms from a physiological point of view, as well as the opportunity that these circulating organelles offer in diagnostics and therapeutics. In the present review, we summarize systematically and comprehensively the myriad of works that appeared in the last decade and lighted the discussion about the best opportunities for using EVs in liver disease therapeutics. |
| Databáze: | OpenAIRE |
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