Molecular characterization and antimicrobial susceptibilities of extra-intestinal Clostridium difficile isolates
| Autor: | Ellie J. C. Goldstein, Limin Zheng, David M. Lyerly, Christopher W. Genheimer, Diane M. Citron, Robert J. Carman, Stephanie F. Sigmon |
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| Rok vydání: | 2007 |
| Předmět: |
Imipenem
Tetracycline Bacterial Toxins Erythromycin Microbial Sensitivity Tests Biology Microbiology Meropenem Enterotoxins Bacterial Proteins Drug Resistance Bacterial medicine Humans Clostridioides difficile Clindamycin biochemical phenomena metabolism and nutrition Clostridium difficile bacterial infections and mycoses Anti-Bacterial Agents Intestines Metronidazole Phenotype Infectious Diseases Clostridium Infections Vancomycin medicine.drug |
| Zdroj: | Anaerobe. 13:114-120 |
| ISSN: | 1075-9964 |
| DOI: | 10.1016/j.anaerobe.2007.04.001 |
| Popis: | Amongst 25 extra-intestinal clinical isolates of Clostridium difficile, A(+)B(+) (72%) and A(-)B(+) (4%) toxigenic phenotypes, as well as the non-toxigenic phenotype (A(-)B(-)) (24%), were identified. The A(-)B(-) isolates did not express toxin, yet carried part of the tcdA and tcdB gene and are of a previously unreported toxinotype. Six A(+)B(+) isolates also carried binary toxin genes. Resistance to erythromycin (20%), clindamycin (48%), tetracycline (16%), moxifloxacin (16%) and imipenem (11%) occurred but with no apparent correlation to phenotype. None of the strains was resistant to vancomycin or metronidazole. Imipenem-resistance decreased by EDTA, but susceptibility to meropenem suggests the presence of an imipenem specific metalloenzyme. |
| Databáze: | OpenAIRE |
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