Similar fecal immunochemical test results in screening and referral colorectal cancer
| Autor: | Leo G. M. van Rossum, Paul Fockens, Jochim S. Terhaar sive Droste, René W M van der Hulst, Gerrit A. Meijer, Jan B.M.J. Jansen, Robert J.F. Laheij, Evelien Dekker, Chris J. J. Mulder, Frank A. Oort, Anneke A. Bouman, Anne F. van Rijn, Sietze T. van Turenhout |
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| Přispěvatelé: | Gastroenterology and hepatology, Pathology, Clinical chemistry, CCA - Oncogenesis, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, Gastroenterology and Hepatology |
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Brief Article Referral Colorectal cancer Population Colonoscopy Gastroenterology fluids and secretions Internal medicine medicine Humans Mass Screening Single-Blind Method Prospective Studies Prospective cohort study education Referral and Consultation Mass screening Aged Neoplasm Staging education.field_of_study medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease Immunohistochemistry digestive system diseases Surgery Logistic Models Evaluation of complex medical interventions [NCEBP 2] Occult Blood Cohort T-stage Female Colorectal Neoplasms business |
| Zdroj: | World Journal of Gastroenterology, 18, 38, pp. 5397-403 World Journal of Gastroenterology, 18, 5397-403 World Journal of Gastroenterology, 18(38), 5397-5403. WJG Press van Turenhout, S T, van Rossum, L G M, Oort, F A, Laheij, R J F, van Rijn, A F, Terhaar sive Droste, J S, Fockens, P, van der Hulst, R W M, Bouman, A A, Jansen, J B M J, Meijer, G A, Dekker, E & Mulder, C J J 2012, ' Similar fecal immunochemical test results in screening and referral colorectal cancer ', World Journal of Gastroenterology, vol. 18, no. 38, pp. 5397-5403 . https://doi.org/10.3748/wjg.v18.i38.5397 World journal of gastroenterology, 18(38), 5397-5403. WJG Press |
| ISSN: | 1007-9327 |
| DOI: | 10.3748/wjg.v18.i38.5397 |
| Popis: | Contains fulltext : 109531.pdf (Publisher’s version ) (Open Access) AIM: To improve the interpretation of fecal immunochemical test (FIT) results in colorectal cancer (CRC) cases from screening and referral cohorts. METHODS: In this comparative observational study, two prospective cohorts of CRC cases were compared. The first cohort was obtained from 10 322 average risk subjects invited for CRC screening with FIT, of which, only subjects with a positive FIT were referred for colonoscopy. The second cohort was obtained from 3637 subjects scheduled for elective colonoscopy with a positive FIT result. The same FIT and positivity threshold (OC sensor; >/= 50 ng/mL) was used in both cohorts. Colonoscopy was performed in all referral subjects and in FIT positive screening subjects. All CRC cases were selected from both cohorts. Outcome measurements were mean FIT results and FIT scores per tissue tumor stage (T stage). RESULTS: One hundred and eighteen patients with CRC were included in the present study: 28 cases obtained from the screening cohort (64% male; mean age 65 years, SD 6.5) and 90 cases obtained from the referral cohort (58% male; mean age 69 years, SD 9.8). The mean FIT results found were higher in the referral cohort (829 +/- 302 ng/mL vs 613 +/- 368 ng/mL, P = 0.02). Tissue tumor stage (T stage) distribution was different between both populations [screening population: 13 (46%) T1, eight (29%) T2, six (21%) T3, one (4%) T4 carcinoma; referral population: 12 (13%) T1, 22 (24%) T2, 52 (58%) T3, four (4%) T4 carcinoma], and higher T stage was significantly associated with higher FIT results (P < 0.001). Per tumor stage, no significant difference in mean FIT results was observed (screening vs referral: T1 498 +/- 382 ng/mL vs 725 +/- 374 ng/mL, P = 0.22; T2 787 +/- 303 ng/mL vs 794 +/- 341 ng/mL, P = 0.79; T3 563 +/- 368 ng/mL vs 870 +/- 258 ng/mL, P = 0.13; T4 not available). After correction for T stage in logistic regression analysis, no significant differences in mean FIT results were observed between both types of cohorts (P = 0.10). CONCLUSION: Differences in T stage distribution largely explain differences in FIT results between screening and referral cohorts. Therefore, FIT results should be reported according to T stage. |
| Databáze: | OpenAIRE |
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