Periventricular lesions and MS diagnostic criteria in young adults with typical clinically isolated syndromes
| Autor: | Olga Ciccarelli, Wallace J Brownlee, David Miller, Katherine A. Miszkiel, Daniel R. Altmann |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Multiple Sclerosis Time Factors Dissemination in time Adolescent Cerebral Ventricles Decision Support Techniques 030218 nuclear medicine & medical imaging Lesion Young Adult 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Humans Medicine In patient Young adult Retrospective Studies Clinically isolated syndrome medicine.diagnostic_test business.industry Multiple sclerosis Reproducibility of Results Magnetic resonance imaging McDonald criteria Middle Aged Prognosis medicine.disease Magnetic Resonance Imaging Neurology Disease Progression Female Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery Demyelinating Diseases |
| ISSN: | 1352-4585 |
| Popis: | In patients who present with a clinically isolated syndrome (CIS), whose features are suggestive of multiple sclerosis (MS), fulfilling McDonald 2010 magnetic resonance imaging (MRI) criteria for dissemination in space (DIS) and dissemination in time (DIT) enables a diagnosis of MS. While ⩾1 periventricular lesion is included in the 2010 DIS criteria, earlier McDonald criteria required ⩾3 periventricular lesions to confirm DIS and recent Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS)-recommended DIS criteria also require ⩾3 lesions. We investigated the effect of varying the required number of periventricular lesions and found that the best combination of specificity and sensitivity for clinically definite MS was seen for ⩾1 periventricular lesion using both the McDonald 2010 and MAGNIMS 2016 criteria. |
| Databáze: | OpenAIRE |
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