Investigation of ERG Gene Expression in Iranian Patients with Multiple Sclerosis
| Autor: | Mohammad-Taghi Kardi, Nasrin Yazdanpanahi, Masoud Etemadifar, Elahe Shams, Shirin Shahbazi |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Multiple Sclerosis Adolescent Immunology Disease Biology Iran Real-Time Polymerase Chain Reaction 03 medical and health sciences Young Adult 0302 clinical medicine Transcriptional Regulator ERG Gene expression medicine Humans Regulation of gene expression Multiple sclerosis Case-control study General Medicine Middle Aged medicine.disease 030104 developmental biology Real-time polymerase chain reaction Gene Expression Regulation Case-Control Studies Cancer research Female Erg 030217 neurology & neurosurgery |
| Zdroj: | Immunological investigations. 47(4) |
| ISSN: | 1532-4311 |
| Popis: | Multiple sclerosis (MS) is a common neuro-inflammatory disease arising from interplay of multiple genetic and nongenetic factors. The complex etiology of MS highlights the importance of investigation in various populations exposed to different genetic and environmental risk factors and combination of the results of these studies for elucidation of the MS underlying mechanisms and management of this disease. The role of ETS-related gene (ERG) in inflammation and immune response has been suggested by different investigations. However, a very limited number of studies have been performed about the contribution of this gene in pathogenesis and risk of MS.The present study investigated the association of ERG mRNA expression with MS by reverse transcription quantitative PCR (RT-qPCR) for the first time in peripheral blood samples of 50 Iranian MS patients and 50 controls.There was no statistically significant difference in the expression of the ERG between patients and controls. Also, no correlation was detected between the expression of this gene and age of onset, disease duration and Expanded Disability Status Scale.The findings of the current study revealed no association between ERG expression and MS, at least in the Iranian patients studied. However, more in-depth and comprehensive investigations should be included to evaluate the exact relevance of this gene to the development of autoimmune diseases such as MS. |
| Databáze: | OpenAIRE |
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