Does lymph node ratio affect prognosis in gastroesophageal cancer?
| Autor: | Leon H. Pachter, Antonio Pinna, Steven P. Cohen, Ioannis Hatzaras, Elliot Newman, Antonio Masi, Russell S. Berman, Marcovalerio Melis |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Oncology Prognostic factor medicine.medical_specialty Esophageal Neoplasms Adenocarcinoma Resection Gastroesophageal cancer Stomach Neoplasms Internal medicine medicine Humans Neoplasm Invasiveness In patient Lymph node Aged Retrospective Studies Aged 80 and over business.industry Cancer General Medicine Middle Aged Prognosis medicine.disease medicine.anatomical_structure Lymphatic Metastasis Multivariate Analysis Lymph Node Excision Female Surgery Lymph business Median survival |
| Zdroj: | The American Journal of Surgery. 210:443-450 |
| ISSN: | 0002-9610 |
| Popis: | Increasing evidence suggests that the ratio of number of nodes harboring metastatic cancer to the total number of lymph nodes examined (lymph node ratio, LNR) may affect survival after esophagogastric resection for cancer. We analyzed the impact of LNR in overall survival in patients undergoing esophagogastric resection for cancer.Patients who underwent gastroesophageal resection for cancer (1998 to 2008) were categorized into 4 groups according to their LNR: 113 patients had negative nodes (N0), 86 LNR less than .3, 40 LNR .31 to .6, and 47 LNR greater than .6. Study endpoint was overall median survival.Higher LNR was associated (P.001) with more advanced stage and adverse pathologic features (eg, grading, venous/perineural invasion). Multivariate analysis demonstrated that LNR is an independent predictor of survival.In our experience, LNR correlates with adverse pathologic features and is a negative prognostic factor in patients undergoing radical resection for gastroesophageal cancer. |
| Databáze: | OpenAIRE |
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