The role of DNA demethylation in liver to pancreas transdifferentiation

Autor:	Adi Har-Zahav, Daniela Lixandru, David Cheishvili, Ioan Valentin Matei, Ioana Raluca Florea, Veronica Madalina Aspritoiu, Inna Blus-Kadosh, Irit Meivar-Levy, Andreea Madalina Serban, Irinel Popescu, Moshe Szyf, Sarah Ferber, Simona Olimpia Dima
Rok vydání:	2022
Předmět:	DNA Demethylation Liver Cell Transdifferentiation Insulins Molecular Medicine Medicine (miscellaneous) Cell Biology DNA Biochemistry Genetics and Molecular Biology (miscellaneous) Pancreas Chromatin Transcription Factors
Zdroj:	Stem cell researchtherapy. 13(1)
ISSN:	1757-6512
Popis:	Background Insulin producing cells generated by liver cell transdifferentiation, could serve as an attractive source for regenerative medicine. The present study assesses the relationship between DNA methylation pTFs induced liver to pancreas transdifferentiation. Results The transdifferentiation process is associated with DNA demethylation, mainly at gene regulatory sites, and with increased expression of these genes. Active inhibition of DNA methylation promotes the pancreatic transcription factor-induced transdifferentiation process, supporting a causal role for DNA demethylation in this process. Conclusions Transdifferentiation is associated with global DNA hypomethylation, and with increased expression of specific demethylated genes. A combination of epigenetic modulators may be used to increase chromatin accessibility of the pancreatic transcription factors, thus promoting the efficiency of the developmental process.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ab52c58808afdd32e19c9009de4e8e https://pubmed.ncbi.nlm.nih.gov/36114514 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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