Male adiposity, sperm parameters and reproductive hormones: An updated systematic review and collaborative meta-analysis
| Autor: | Pedro Javier Torres, Jordi Salas-Salvadó, Nicolás David Ramírez, Nerea Becerra-Tomás, Albert Salas-Huetos, Reza Abed, Eugenia Mercedes Luque, A. C. Martini, Kenneth I. Aston, Leila Maghsoumi-Norouzabad, Emma R. James, Douglas T. Carrell, Ahmad Zare Javid, Timothy G. Jenkins |
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| Rok vydání: | 2020 |
| Předmět: |
Male
endocrine system Endocrinology Diabetes and Metabolism Physiology 030209 endocrinology & metabolism Overweight Vitality 03 medical and health sciences Semen quality 0302 clinical medicine Sex Hormone-Binding Globulin medicine Humans Inhibins Testosterone 030212 general & internal medicine Obesity Infertility Male Adiposity urogenital system business.industry Public Health Environmental and Occupational Health medicine.disease Sperm Spermatozoa Semen Analysis Meta-analysis Underweight medicine.symptom business |
| Zdroj: | Obesity reviews : an official journal of the International Association for the Study of ObesityREFERENCES. 22(1) |
| ISSN: | 1467-789X |
| Popis: | The present updated systematic review and meta-analysis aims to summarize the evidence from published studies with low risk for any important bias (based on methodological quality assessment) investigating the potential associations of adiposity with sperm quality and reproductive hormones. We conducted a systematic search of the literature published in MEDLINE-PubMed and EMBASE through June 2019. Based on the criteria in our review, 169 eligible publications were used for data abstraction. Finally, 60 articles were included in the qualitative analysis and 28 in the quantitative analysis. Our systematic review results indicated that overweight and/or obesity were associated with low semen quality parameters (i.e., semen volume, sperm count and concentration, sperm vitality and normal morphology) and some specific reproductive hormones (e.g., inhibin B, total testosterone and sex hormone-binding globulin). Overweight and/or obesity were also positively associated with high estradiol concentrations. Meta-analysis indicated that overweight and/or obesity categories were associated with lower sperm quality (i.e., semen volume, sperm count and concentration, sperm vitality, total motility and normal morphology), and underweight category was likewise associated with low sperm normal morphology. In conclusion, our results suggest that maintaining a healthy body weight is important for increasing sperm quality parameters and potentially male fertility. |
| Databáze: | OpenAIRE |
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